胃底腺息肉合并结直肠肿瘤发生危险因素的临床研究

Clinical Study on the Risk Factors of Fundic Gland Polyps Combined with Colorectal Tumor

目的探究胃底腺息肉合并结直肠肿瘤的危险因素。方法回顾性分析2018年1月至2019年7月于锦州医科大学附属第一医院消化科门诊及住院行胃肠镜检查且诊断为胃底腺息肉的患者179例,根据肠镜结果分为对照组(仅存在胃底腺息肉)113例和病例组(胃底腺息肉合并结直肠肿瘤)66例。收集患者的基本个人资料及相关病史,通过统计学方法分析胃底腺息肉合并结直肠肿瘤的危险因素。结果在病例组中,患者的年龄、性别、吸烟和25-羟维生素D水平均与对照组存在差异且具有统计学意义。而二分类Logistic回归模型分析显示女性、年龄≥50岁、吸烟及低25-羟维生素D水平均为胃底腺息肉合并结直肠肿瘤的危险因素。结论在临床上女性、年龄≥50岁、吸烟及血浆25-羟维生素D水平低的胃底腺息肉患者需建议进行肠镜筛查,以便尽早发现病变。

Objective To explore the risk factors of fundic gland polyps combined with colorectal tumor.Methods 179 cases of patients diagnosed with fundic gland polyps by gastrointestinal endoscopes at the gastroenterology department of the First Affiliated Hospital of Jinzhou Medical University from January 2018 to July 2019 were retrospectively analyzed.According to gastroscopy results,113 cases were taken as control group(only with fundic gland polyps)and 66 cases were put into case group(with fundic gland polyps combined with colorectal tumor).The patients’basic personal data and related medical history were collected.The risk factors of fundic gland polyps combined with colorectal tumor were analyzed by statistical method.Results Compared with the patients in control group,the age and gender of patients in the case group were statistically different.Multivariate Logistic regression analysis showed that risk factors for fundic gland polyps combined with colorectal tumors included female,age(over 50 years old),smoking,and low 25-hydroxy vitamin D level.Conclusion Clinically,patients with fundic gland polyps and with such risk factors as being female,aged over 50 years old,smoking and with low plasma 25-hydroxy vitamin D level are advised for colonoscopy screening in order to detect premalignant lesions as soon as possible.