肠道菌群参与宿主免疫应答的作用及机制研究进展

Role and mechanism of gut microbiota involved in host immune response

肠道菌群作为动物体内重要的组成部分,能够直接参与机体的免疫调控作用,促进机体免疫系统发育,维持正常免疫功能。同时,免疫系统对肠道菌群又有调控和制约作用。本文主要综述了肠道菌群的组成以及影响肠道菌群变化的因素,系统阐述了肠道菌群与疾病相互作用的机制,总结了肠道菌群在宿主感染与免疫应答中的作用,为开展肠道菌群参与机体免疫应答的机制方面的研究提供新的思路。

Being an important component to the health of the host,the intestinal flora can participate in the immune regulation of the body,promote the development of the body’s immune system,and maintain normal immune function.At the same time,the immune system has regulatory and restrictive effects on the intestinal flora.This paper reviews the species of intestinal flora,factors affecting the changes in intestinal flora,the mechanism of interaction between intestinal microbiota and pathogens,and the role in host infection and immune response.This paper will also provide new insights into research on the mechanism of intestinal flora participating in the immune response.