不同心功能分级慢性充血性心力衰竭患者血清NGAL sIL-2R水平检测分析

Detection and analysis of serum NGAL and sil-2R levels in patients with chronic congestive heart failure with different heart function classification

目的探讨不同心功能分级慢性充血性心力衰竭患者血清中性粒细胞明胶酶相关脂质运载蛋白、可溶性白细胞介素-2受体水平的变化及临床意义.方法将94例慢性充血性心力衰竭患者设为观察组,依据美国纽约心脏病协会心功能分级标准分为Ⅰ级20例、Ⅱ级30例、Ⅲ级27例、Ⅳ级17例;将120名健康志愿者设为对照组.统计两组性别、年龄、体质量指数、舒张压、收缩压、吸烟史等一般资料,检测两组血清中性粒细胞明胶酶相关脂质运载蛋白、可溶性白细胞介素-2受体水平,对检测结果进行对比分析.结果观察组体质量指数及血清中性粒细胞明胶酶相关脂质运载蛋白、可溶性白细胞介素-2受体水平均显著高于对照组(P<0.01),收缩压显著低于对照组(P<0.01);观察组不同心功能分级患者血清中性粒细胞明胶酶相关脂质运载蛋白、可溶性白细胞介素-2受体水平比较差异均有统计学意义(P<0.01),且患者中性粒细胞明胶酶相关脂质运载蛋白、可溶性白细胞介素-2受体水平均随心功能分级升高而依次升高(P<0.01).结论慢性充血性心力衰竭患者血清中性粒细胞明胶酶相关脂质运载蛋白、可溶性白细胞介素-2受体水平随着病情的加重而升高,临床上监测其血清水平变化,可为该病的诊治提供理论依据.

Objective To explore the changes and clinical significance of serum NGAL and sil-2R levels in patients with chronic congestive heart failure with different heart function classification.Methods A total of 94 patients with chronic congestive heart failure were selected as the observation group.According to.NYUA cardiac function classification criteria,they were divided into grade Ⅰ(20 cases),grade Ⅱ(30 cases),grade Ⅲ(27 cases),and grade Ⅳ(17 cases).120 healthy volunteers were set as the control group.Gender,age,body mass index,diastolic blood pressure,systolic blood pressure,smoking history of the two groups were analyzed.The serum NGAL and sIL-2R levels were detected in two groups,and the test results were compared and analyzed.Results The body mass index and serum NGAL and sIL-2R levels in the observation group were significantly higher than those in the control group(P<0.01),and the systolic blood pressure was significantly lower than that in the control group(P<0.01).There were significant differences in serum NGAL and sIL-2R levels in patients with different cardiac function grades in the observation group(P<0.01),and the levels of NGAL and sIL-2R in patients increased sequentially with increasing cardiac function grades(P<0.01).Conclusions With the exacerbation of chronic congestive heart failure patients,serum NGAL and sIL-2R levels gradually increase.There is an immune dysfunction in the occurrence and development of lesions,and there is a close relationship between heart and kidney disease.Clinical monitoring of serum NGAL and sIL-2R levels in patients can provide a theoretical basis for the diagnosis and treatment of the disease.