利培酮联合认知疗法治疗首发精神分裂症临床疗效及对患者生活质量的影响

Effects of risperidone combined with cognitive therapy in the treatment of first-onset schizophrenia and its effect on patients'quality of life

目的探讨利培酮联合认知疗法治疗首发精神分裂症患者的临床疗效以及对生活质量的影响.方法将79例首发精神分裂症患者按入院顺序分为A组39例、B组40例,均常规口服利培酮治疗,B组联合认知疗法辅助治疗,观察3个月.治疗前后采用阳性与阴性症状量表评定临床疗效,生活质量综合评定问卷评定生活质量.结果治疗3个月两组阳性与阳性症状量表评分较治疗前显著下降(P<0.01),B组评分显著低于A组(P<0.01);两组生活质量综合评定问卷评分较治疗前显著升高(P<0.01),B组评分显著高于A组(P<0.01);B组总有效率(90.0%)显著高于A组(71.8%).结论利培酮联合认知疗法治疗精神分裂症临床疗效显著,并能提高患者的生活质量,优于单用利培酮治疗,值得在临床推广应用.

Objective To observe the effects of risperidone combined with cognitive therapy in the treatment of first-onset schizophrenia and its effect on patients'quality of life.Methods 79 patients with early onset first-episode schizophrenia were divided into group A and group B(A=39,B=40),Patients in group A received risperidone treatment,while patients in group B received cognitive therapy assisted treatment on the basis of conventional treatment for 3 months.Before and after treatment,PANSS was used to assess the clinical efficacy,and GQOLI-74 was used to assess the quality of life.Results After 3 months of treatment,the PANSS score of the two groups was significantly lower than before treatment(P<0.01),and the score of group B was significantly lower than that of group A(P<0.01).The PANSS score of the two groups was significantly higher than before treatment(P<0.01).The score of group B was significantly higher than that of group A(P<0.01).The total effective rate of group B(90.0%)was significantly higher than that of group A(71.8%).Conclusions The clinical efficacy of risperidone combined with cognitive therapy in the treatment of early onset first-episode schizophrenia is significant,which can improve the quality of life of patients.It is superior to risperidone alone and is worthy of clinical application.