复方五味子提取物对力竭游泳大鼠的抗疲劳作用

Anti-fatigue Effect of Compound Schisandra Extract on Exhausted Swimming Rats

五味子、黄芪、丹参、枸杞和马齿苋均具有较好的抗氧化活性和抗疲劳功效。然而,尚不清楚该5种中药材组合的应用效果。本研究将这5种植物药材进行混合提取,得到了复方五味子提取物。然后考察了不同剂量的复方五味子提取物对力竭游泳大鼠的运动能力和生化指标的影响。研究显示,复方五味子提取物以剂量依赖性方式提高大鼠的力竭游泳时间(p<0.05)。复方五味子提取物以剂量依赖性方式降低血清Lac和BUN水平并升高NEFA水平(p<0.05)。复方五味子提取物显著升高大鼠体内SOD和CAT水平,并显著降低MDA水平(p<0.05)。复方五味子提取物显著降低大鼠血清CK、AST和ALT水平(p<0.05),并减弱骨骼肌组织病变程度。本研究表明,复方五味子提取物具有较好的抗疲劳作用,可通过减少乳酸堆积、增加脂肪动员、减弱氧化应激损伤来提高机体运动能力。

Schisandra chinensis,Astragalus membranaceus,Salvia miltiorrhiza Bunge,Lycium barbarum and Portulaca oleracea have good antioxidant activity and anti-fatigue effect.However,the application effect of the combination of those Chinese herbal medicines is not known.In this study,the five medicinal materials were mixed and extracted,and the compound Schisandra extract was obtained.Then,the effects of different doses of compound Schisandra extract on exercise capacity and biochemical indexes of exhausted swimming rats were investigated.Studies showed that the compound Schisandra extract increased the exhaustive swimming time of rats in a dose-dependent manner(p<0.05).Compound Schisandra extract reduced serum Lac and BUN levels and increased NEFA levels in a dose-dependent manner(p<0.05).Compound Schisandra extract significantly incre-ased SOD and CAT levels and significantly decreased MDA levels in rats(p<0.05).Compound Schisandra extract significantly reduced serum CK,AST and ALT levels(p<0.05)and attenuated skeletal muscle tissue lesions.This study shows that the compound Schisandra extract has a good anti-fatigue effect,which can improve the body’s exercise capacity by reducing lactic acid accumulation,increasing fat mobilization,and weakening oxidative stress damage.