葛根素联合α-硫辛酸治疗糖尿病合并颈动脉粥样硬化的临床研究

Clinical study of puerarin combined with α-lipoic acid in the treatment of diabetes mellitus with carotid atherosclerosis

目的探讨葛根素联合α-硫辛酸治疗糖尿病合并颈动脉粥样硬化的临床效果。方法选取2015年1月~2019年1月鞍钢集团公司总医院收治的糖尿病合并颈动脉粥样硬化患者122例,根据随机数字表法将其分为对照组和研究组,每组61例。对照组在常规治疗的基础上联合α-硫辛酸治疗,研究组在对照组的基础上联合葛根素治疗。比较两组患者临床疗效、糖脂代谢指标及氧化应激指标,记录两组患者治疗期间不良反应发生情况。结果治疗1个月后,研究组的临床总有效率高于对照组,差异有统计学意义(P<0.05)。两组患者治疗前糖化血红蛋白(HbA1c)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)比较,差异无统计学意义(P>0.05);治疗1个月后,两组患者HbA1c比较,差异无统计学意义(P>0.05);两组患者TC、TG、LDL均较治疗前下降,HDL较治疗前升高,且研究组TC、TG、LDL低于对照组,HDL高于对照组,差异均有统计学意义(均P<0.05)。两组患者治疗前血清超氧化物歧化酶(SOD)、丙二醛(MDA)水平比较,差异无统计学意义(P>0.05);治疗1个月后,两组患者SOD较治疗前升高,MDA较治疗前下降,且研究组SOD高于对照组,MDA低于对照组,差异均有统计学意义(均P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论葛根素联合α-硫辛酸治疗糖尿病合并颈动脉粥样硬化,疗效显著,可有效改善患者血脂及氧化应激指标水平,安全性较好,临床应用价值较高。

Objective To investigate the clinical effect of puerarin combined withα-lipoic acid in the treatment of diabetes mellitus with carotid atherosclerosis.Methods A total of 122 patients with diabetes mellitus complicated with carotid atherosclerosis admitted to Ansteel Group Hospital from January 2015 to January 2019 were selected and they were divided into the control group and the study group according to the random number table method,with 61 cases in each group.The control group was treated withα-lipoic acid on the basis of routine treatment,and the study group was treated withα-lipoic acid on the basis of the control group.The clinical efficacy,glucose and lipid metabolism indexes and oxidative stress indexes of the two groups were compared,and the occurrence of adverse reactions of the two groups during treatment was recorded.Results After one month of treatment,the total clinical effective rate of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference between the two groups in glycosylated hemoglobin(HbA1c),total cholesterol(TC),triglyceride(TG),low-density lipoprotein(LDL)and high-density lipoprotein(HDL)(P>0.05).After onemonth of treatment,there was no significant difference in HbA1cbetween the two groups(P>0.05).In both groups,TC,TG and LDL decreased and HDL increased compared with that before treatment,and TC,TG and LDL in the study group were lower than those in the control group and HDL was higher than those in the control group,with statistically significant differences(all P<0.05).There was no statistically significant difference in serum superoxide dismutases(SOD)and malondialdehyde(MDA)levels between the two groups before treatment(P>0.05).After one month of treatment,SOD increased and MDA decreased in the two groups,and SOD in the study group was higher than that in the control group,while MDA was lower than that in the control group,with statistically significant differences(all P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Puerarin combined withα-lipoic acid in the treatment of diabetes mellitus with carotid atherosclerosis has a significant effect,and can effectively improve the level of blood lipid and oxidative stress index in patients,with a good safety and high clinical application value.