布洛芬联合盐酸米诺环素对重度慢性牙周炎基础治疗效果及炎性因子的影响

Effect of Ibuprofen combined with Minocycline Hydrochloride on basic treatment and inflammatory factors of severe chronic periodontitis

目的探讨布洛芬联合盐酸米诺环素对重度慢性牙周炎基础治疗效果及炎性因子的影响。方法选取2017年3月~2019年3月浙江省金华市中心医院诊治的重度慢性牙周炎患者78例,根据随机数字表法将其分为研究组(39例)、对照组(39例)。对照组给予牙周机械治疗,研究组在对照组基础上联合布洛芬治疗,治疗4周后比较两组临床疗效、炎性因子水平、免疫功能、牙周指标及不良反应。结果研究组治疗4周后临床总有效率高于对照组(P<0.05)。与治疗前比较,两组治疗4周后白细胞介素(IL)-6、IL-8、肿瘤坏死因子-α、超敏C反应蛋白均下降,且研究组低于对照组(P<0.05)。与治疗前比较,两组治疗4周后CD4^+、CD4^+/CD8^+均升高,CD8^+则降低(P<0.05),研究组CD4^+、CD4^+/CD8^+高于对照组,而CD8^+则低于对照组(P<0.05)。与治疗前比较,两组治疗4周后龈沟出血指数、菌斑指数和牙周袋深度均降低,且研究组低于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论布洛芬联合盐酸米诺环素治疗重度慢性牙周炎患者,可有效提高患者免疫功能,减轻炎性反应,且用药安全性较好,疗效确切。

Objective To investigate the effect of Ibuprofen combined with Minocycline Hydrochlorideon basic treatment and inflammatory factors of severe chronic periodontitis.Methods A total of 78 patients with severe chronic periodontitis diagnosed and treated in Jinhua Central Hospital of Zhejiang Province from March 2017 to March 2019 were selected.They were divided into study group(39 cases)and control group(39 cases)according to the random number table method.The control group was given periodontal mechanical therapy.The study group was treated with Ibuprofen on the basis of the control group.After 4 weeks of treatment,the clinical effect,inflammatory factor level,immune function,periodontal index and adverse reactions were compared between the two groups.Results The total clinical effective rate of the study group was higher than that of the control group after 4 weeks of treatment(P<0.05).Com pared with before treatment,interleukin(IL)-6,IL-8,tumour necrosis factor-αand hypersensitive C-reactive protein in both groups were decreased after 4 weeks of treatment,and the study group were lower than those of the control group(P<0.05).Compared with before treatment,CD4^+and CD4^+/CD8^+in both groups were increased after 4 weeks of treatment,while CD8^+was decreased(P<0.05).The CD4^+and CD4^+/CD8^+in the study group were higher than those in the control group,while CD8^+was lower than that in the control group(P<0.05).Compared with before treatment,the gingival sulcus bleeding index,plaque index and periodontal pocket depth of the two groups were all reduced after 4weeks of treatment,and the study group were lower than those of the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Ibuprofen combined with Minocycline Hydrochloride in the treatment of severe chronic periodontitis can effectively improve the immune function and alleviate inflammatory reaction,and the drug is safe and effective.