左西孟旦治疗心肌梗死伴心力衰竭的疗效观察

Curative Effect of Levosimendan on Myocardial Infarction Combined with Heart Failure

目的:研究左西孟旦治疗心肌梗死伴心力衰竭的疗效。方法:将90例心肌梗死伴心力衰竭患者随机分为观察组与对照组,各45例,对照组给予常规治疗,观察组在对照组的基础上给予左西孟旦治疗。观察两组治疗效果以及治疗前后B型钠尿肽(BNP)、左心室射血分数(LVEF)、左室舒张末期内径(LVEDD)、血压(BP)水平和心率以及不良反应发生情况。结果:观察组治疗总有效率高于对照组;与治疗前比较,两组治疗后LVEDD、BNP心率和血压水平均下降,LVEF上升,且观察组变化优于对照组;差异均有统计学意义(P<0. 05);两组不良反应差异无统计学意义(P>0. 05)。结论:左西孟旦能有有效改善心肌梗死伴心力衰竭患者临床症状,提高治疗效果,使用安全。

Objective:To study the curative effect of levosimendan on myocardial infarction combined with heart failure.Methods:The 90 patients with myocardial infarction and heart failure who were diagnosed in the hospital were divided into the observation group and control group based on the random number table method with 45 cases in each group. The control group was given routine treatment, while the observation group was given levosimendan treatment.The levels of B-type natriuretic peptide(BNP),left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD) and blood pressure(BP),heart rate,occurrence of adverse reactions with the curative effect were observed between the two groups before and after the treatment.Results:The total response rate of treatment in observation group was significantly higher than that in control group(P<0. 05). Compared with those before treatment,LVEDD,BNP,heart rate and blood pressure level in both groups were significantly decreased after treatment, while LVEF was significantly increased. The increase or decrease trend in the observation group was more obvious than that in control group(P<0. 05). There was no statistically significant difference in adverse reactions between the two groups(P>0. 05).Conclusions:Levosimendan can effectively improve clinical symptoms of patients with myocardial infarction and heart failure and the curative effect with the application safer.