依达拉奉联合巴曲酶治疗脑梗死后非痴呆型血管性认知功能障碍的效果及对神经功能的影响

Effect of edaravone combined with batroxobin on vascular cognitive impairment no dementia after cerebral infarction and its influence on neurological function

目的分析依达拉奉联合巴曲酶治疗脑梗死后非痴呆型血管性认知功能障碍(VCIND)的效果及对神经功能的影响。方法 75例脑梗死后非痴呆型血管性认知功能障碍患者,随机分为研究组(38例)与对照组(37例)。对照组予以胞磷胆碱治疗,研究组在对照组基础上予以依达拉奉联合巴曲酶治疗。比较两组神经功能评分、脑血管的储存功能[血流灌注指数(PI)、脑血管储备能力(CVR)、脑动脉平均血流量(MCV)增加值]、认知功能评分。结果治疗后,研究组神经功能评分(28.87±0.38)分高于对照组的(27.15±1.06)分,差异有统计学意义(P<0.05)。治疗后,研究组CVR(47.13±6.36)%、MCV增加值(35.13±5.26)cm/s高于对照组的(37.24±5.61)%、(23.38±3.91)cm/s, PI(0.40±0.12)低于对照组的(0.62±0.19),差异均有统计学意义(P<0.05)。治疗后,研究组认知功能评分(26.24±1.64)分高于对照组的(22.15±2.15)分,差异有统计学意义(P<0.05)。结论脑梗死后非痴呆型血管性认知功能障碍患者应用巴曲酶联合依达拉奉治疗,能有效提高患者神经功能及认知功能指标,改善其脑血管的储存功能指标。

Objective To analyze edaravone combined with batroxobin on vascular cognitive impairment no dementia(VCIND) after cerebral infarction and its influence on neurological function. Methods A total of 75 patients with vascular cognitive impairment no dementia after cerebral infarction were randomly divided into research group(38 cases) and control group(37 cases). The control group was treated by citicoline, and the research group was treated by edaravone combined with batroxobin. The neurological score, cerebrovascular storage function [perfusion index(PI), cerebrovascular reserve index(CVR) and mean corpuscular volume(MCV) increased value] and cognitive function score were compared between the two groups. Results After treatment, the neurological score of the research group was(28.87±0.38) points, which was higher than that of the control group(27.15±1.06) points, and the difference was statistically significant(P<0.05). After treatment, CVR(47.13±6.36)% and MCV increased value(35.13±5.26) cm/s of the research group were higher than those of the control group(37.24±5.61)% and(23.38±3.91) cm/s, and PI(0.40±0.12) was lower than that of the control group(0.62±0.19). The difference was statistically significant(P<0.05). After treatment, the cognitive function score(26.24±1.64) points of the research group was higher than that of the control group(22.15± 2.15) points, and the difference was statistically significant(P<0.05). Conclusion For patients with vascular cognitive impairment with no dementia after cerebral infarction, edaravone combined with batroxobin can effectively improve the neurological function, cognitive function and the storage function of cerebral vessels.