经颅磁刺激治疗脊髓损伤痉挛的研究进展

Recent advances in transcranial magnetic stimulation for spasticity in spinal cord injury

痉挛是脊髓损伤后主要的并发症之一,据统计70%脊髓损伤患者伴有不同程度的痉挛,不仅影响日常生活能力、改变生活方式、降低生活质量,也是限制脊髓损伤患者运动功能恢复的主要因素。因此,新颖、安全、有效的抗痉挛疗法的开发及临床应用至关重要。目前经颅磁刺激临床应用广泛,通过增强中枢神经系统的兴奋,成为脊髓损伤痉挛患者可选择的治疗手段。文章主要对经颅磁刺激、Theta节律刺激应用于脊髓损伤痉挛的研究现状以及重复性经颅磁刺激治疗可能存在的机制进行综述。

Spasticity is one of the major complications after spinal cord injury.According to statistics,70%of patients with spinal cord injury are accompanied by spasticity in different degrees.It not only affects the ability of patients in daily life,changes lifestyle,and reduces the quality of life,but also is a major factor restricting the recovery of motor function in patients with spinal cord injury.Therefore,the development and clinical application of novel,safe and effective antispasmodic therapy is very important.At present,transcranial magnetic stimulation(TMS)is widely used in clinical practice.By enhancing the excitement of the central nervous system,it has become an alternative treatment for patients with spasticity caused by spinal cord injury.This paper mainly reviews the research status of TMS,Theta rhythm stimulation in spasticity of spinal cord injury and the possible mechanism of repetitive TMS treatment.