淋巴细胞比值对中晚期非小细胞肺癌患者预后的评估价值

The prognostic value of lymphocyte ratio in patients with advanced non-small cell lung cancer

目的探讨中性粒细胞与淋巴细胞比值(NLR)及血小板与淋巴细胞比值(PLR)对不同部位中晚期NSCLC患者预后的评估价值。方法收集120例中晚期NSCLC患者的临床病理资料,并计算NLR和PLR值。随访观察中心型、周围型NSCLC患者的生存预后。分析NLR和PLR对不同部位NSCLC患者的预后评价。结果 NLR值与肿瘤部位、吸烟、N分期及转移病灶个数存在明显相关(P <0.05);PLR值则与肿瘤部位、T分期及转移病灶个数存在明显相关(P <0.05);中央型NSCLC患者中,低NLR组、低PLR组生存时间均显著高于高NLR及高PLR组,差异有统计学意义(P <0.05);周围型NSCLC患者中,低NLR组、低PLR组生存时间均显著高于高NLR组及高PLR组,差异有统计学意义(P <0.05)。结论NLR值、PLR值升高均可提示中心型、周围型患者预后不良,但NLR对于不同部位NSCLC预后的判断价值更高。

Objective To investigate the prognostic significance of NLR and PLR in patients with advanced NSCLC at different sites. The prognostic value of lymphocyte ratio in patients with advanced non-small cell lung cancer. Methods The clinicopathological data of 120 patients with advanced NSCLC were collected and the values of NLR and PLR were calculated. The survival and prognosis of patients with central and peripheral NSCLC were observed. NLR and PLR were used to evaluate the prognosis of NSCLC patients in different sites. Results NLR value was significantly correlated with tumor location, smoking, N stage and the number of metastases(P < 0.05);PLR value was significantly correlated with tumor location, T stage and the number of metastases(P < 0.05);survival time of low NLR group and low PLR group was significantly higher than that of high NLR and high PLR group in Central NSCLC(P < 0.05);survival time of low NLR group and low PLR group in peripheral NSCLC was significantly higher than that of high NLR and high PLR group(P < 0.05). All of them were significantly higher than those in high NLR group and high PLR group(P < 0.05). Conclusion The increase of NLR and PLR may indicate the poor prognosis of central and peripheral NSCLC, but NLR has a higher value in judging the prognosis of NSCLC in different parts.