某院1507例药品不良反应报告分析

Analysis on 1507 ADR case reports in a hospital

目的调查某院近十年发生的不良反应情况,了解医院药品不良反应(ADR)发生的特点及一般规律,为临床合理用药提供参考。方法采用回顾性方法,对本院2009~2018年收集并上报的不良反应报告1 507例行统计分析、评价。结果 1 507例ADR报告中,女性多于男性,60岁以上人群616例,占40.88%,所占比例最大。静脉滴注给药引发ADR比例最高,占78.97%。引起ADR的18类药品中最多的为抗感染药,共391例,占总例数的22.72%。ADR累及器官或系统以皮肤及其附件损害最为常见,占42.66%。结论应加强和重视ADR的报告与监测工作,保障合理用药。

Objective To review the 1 507 adverse drug reactions in the first affiliated hospital of Baotou medical college in the past ten years to investigate the rules and characteristics of adverse drug reactions, so as to provide a reference for clinical rational drug use. Methods By retrospective study, 1 507 ADR cases were collected in the hospital from 2009 to 2018, and submitted to statistical analysis, evaluation, according to the ADR criteria of causality. Results Among the 1507 ADR cases, the number of women were more than men, the ADR was more often seen in adults aged over 60 years(40.88%). 78.97% of ADR were induced by intravenous drip. 18 kinds of drugs were reported. The ADR induced by antimicrobials was the highest(391 cases, 22.72%). The ADR appeared mainly as lesions of skin and its appendants(42.66%). Conclusion It is important to strengthen the ADR reporting and monitoring in order to guarantee the reasonable drug application.