母乳成分影响婴儿肠道屏障功能的研究进展

Progress in Understanding the Effects of Human Milk Components on Intestinal Barrier Function in Infants

新生儿出生后处于易感免疫状态,适应性免疫系统不成熟,依赖先天免疫系统进行保护。肠道屏障是先天免疫的重要组成部分,主要由黏膜层、肠上皮细胞层和固有层构成。母乳是婴儿最完美的营养来源,还含有丰富的生物活性因子,对新生儿的肠道屏障功能的建立和成熟有至关重要的作用。本文对母乳中低聚糖、磷脂、长链多不饱和脂肪酸、部分活性蛋白及miRNA在婴儿肠道屏障功能方面的作用进行综述。

The newborn is in a susceptible immune state after birth,the adaptive immune system is immature and it relies on the innate immune system for protection.The intestinal barrier is an important component of innate immunity and consists mainly of the mucosal layer,the intestinal epithelial cell layer and the lamina propria.Human milk is the perfect source of nutrition for infants.It is rich in bioactive factors,which is crucial for the establishment and maturation of neonatal intestinal barrier function.This article reviews the roles of oligosaccharides,phospholipids,long-chain polyunsaturated fatty acids,active proteins and miRNAs in breast milk in protecting intestinal barrier function.