酚类化合物干预镉致肝损伤的研究进展

Recent Progress in Understanding the Protective Effect of Phenolics against Cadmium-Induced Liver Injury

镉是环境和食品中常见的一种重金属污染物,会对人体器官尤其是肝脏造成不可逆损伤。研究发现,镉致肝损伤的机制可能与氧化应激的发生有关。酚类化合物普遍存在于植物性膳食中,具有较强的抗氧化能力,近年来,越来越多的研究结果表明,酚类化合物对镉致肝损伤有显著的防治效果。本文综述了酚类化合物干预镉致肝损伤的研究进展,以期为酚类化合物的开发和应用提供理论参考和研究思路。

Cadmium is a common heavy metal pollutant in the environment and foods,which can cause irreversible damage to human organs,especially liver.Previous studies have found that the mechanism of cadmium-induced liver injury may be related to the occurrence of oxidative stress.Phenolic compounds are ubiquitous in plant-based diets and have strong antioxidant capacity.In recent years,more and more studies have shown that phenolic compounds have significant control effects on cadmium-induced liver injury.This paper reviews recent progress in understanding the protective effect of phenolic compounds against cadmium-induced liver injury,in order to provide a theoretical basis and research ideas for the development and application of phenolic compounds.