摘要
通过急性毒性试验、遗传毒性试验和亚急性毒性试验对鲜榨山茶油进行毒理学研究,并做安全性评价。结果表明:鲜榨山茶油对大鼠的急性经口LD50大于10 000 mg/kg,判属实际无毒级;遗传毒性试验(Ames试验、小鼠骨髓细胞微核试验和体外哺乳类细胞染色体畸变试验)结果均为阴性;在大鼠28 d喂养试验中未见动物健康状况、血液生化指标和器官组织形态的异常变化。因此,鲜榨山茶油无急性毒性、遗传毒性和亚急性毒性,具有较高的食用安全性。
Acute toxicity test, genetic toxicity tests and sub-acute toxicity test of fresh pressed oil-tea camellia seed oil were performed to evaluate its safety. The results showed that acute toxicity test in rats demonstrated actual non-toxicity of fresh pressed oil-tea camellia seed due to its LD50 higher than 10 000 mg/kg. The results of genotoxicity tests(Ames test, mouse bone marrow cells micronucleus test and mammalian cell chromosome aberration test in vitro) were negative. No abnormal changes of animal health, biochemical indexes of blood and organ morphology were found in the 28 d feeding test of rats.The fresh pressed oil-tea camellia seed oil had no acute toxicity, genetic toxicity and sub-acute toxicity, so it had high edible safety.
作者
陈劲松
谭传波
杨耀学
赖琼玮
周刚平
张帆
卢芳国
吴苏喜
CHEN Jinsong;TAN Chuanbo;YANG Yaoxue;LAI Qiongwei;ZHOU Gangping;ZHANG Fan;LU Fangguo;WU Suxi(Hunan Great Sanxiang Camellia Oil Co.,Ltd.,Hengyang 421141,Hunan,China;School of Medicine,Hunan University of Chinese Medicine,Changsha 410208,China;School of Chemistry and Bio-engineering,Changsha University of Science&Technology,Changsha 410114,China)
出处
《中国油脂》
CAS
CSCD
北大核心
2020年第3期68-72,73,97,共7页
China Oils and Fats
基金
2018年度湖南省科技重大专项(2018NK1030)。
关键词
鲜榨山茶油
安全性
毒理学
急性毒性
遗传毒性
亚急性毒性
fresh pressed oil-tea camellia seed oil
safety
toxicology
acute toxicity
genetic toxicity
sub-acute toxicity
