术前淋巴细胞与单核细胞比值预测胃癌淋巴结转移的价值

Preoperative lymphocyte to monocyte ratio predicts lymph node metastasis in gastric cancer

目的探讨术前外周血淋巴细胞与单核细胞比值(LMR)对胃癌淋巴结转移的预测价值。方法回顾性分析2014年1月至2017年5月首都医科大学附属北京世纪坛医院行外科治疗的177例胃癌患者。根据ROC曲线确定最佳临界值为3.79,按此临界值将患者分为高LMR组(LMR≥3.79)和低LMR组(LMR<3.79),分析胃癌患者的LMR与淋巴结转移及淋巴结N分期的关系。结果两组患者N分期的LMR值比较结果显示,N1与N2之间差异无统计学意义,但N1和N2均与N3之间差异有统计学意义(均P<0.05)。多因素分析结果表明,LMR是淋巴结转移的独立影响因素。结论LMR对胃癌患者淋巴结转移及淋巴结转移分期有一定预测意义。

Objective To investigate the predictive value of preoperative peripheral blood lymphocyte to monocyte ratio(LMR)for lymph node metastasis in gastric cancer.Methods Data of 177 gastric cancer patients who underwent surgical treatment in Beijing Shijitan Hospital from Jan 2014 to May 2017 were retrospectively analyzed.According to the ROC curve,the optimal critical value is determined to be 3.79.By this value,patients were divided into high LMR group(LMR≥3.79)and low LMR group(LMR<3.79).Patients'clinicopathological characteristics were collected to analyze the relationship between LMR and lymph node metastasis and lymph node N staging.Results A comparison of LMR and N1 and N2 stage between the two groups showed no significant difference,but both N1 and N2 had statistical defference with N3(P<0.05),suggesting a positive correlation between low LMR and high N stage.logistic regression analysis proves that low LMR is significantly correlated with metastatic lymph node when the number was more than 6.Conclusion Low LMR is positively correlated with lymph node metastasis in gastric cancer patients.