定量蛋白组学技术在筛选急性主动脉夹层早期诊断标志物中的研究进展

Advances in Research of Quantitative Proteomics in Screening of Early Diagnostic Markers for Acute Aortic Dissection

急性主动脉夹层(AAD)是一种发病急骤、漏诊率、误诊率和病死率高的灾难性血管疾病。AAD发病机制复杂,涉及多种信号通路和多个蛋白的参与,目前对AAD发病机制的研究尚无突破性进展。探索AAD确切的发病机制、筛选早期诊断生物标志物对于疾病的诊治、改善预后具有重要意义。近年来定量蛋白组学技术已经广泛用于筛选AAD早期诊断标志物的研究,但筛选AAD早期诊断标志物的研究却止步于初步筛查和验证阶段,早期诊断生物标志物的临床实际应用始终未取得突破性进展。

Acute aortic dissection( AAD) is a catastrophic disease with rapid onset,high mortality,high misdiagnosis and high missed diagnosis rate. The pathogenesis of AAD is complicated where multiple channels and proteins are involved,with no breakthrough in the research of its pathogenesis up to now. Exploring the pathogenesis and screening early diagnostic markers of AAD are of great significance for the diagnosis,treatment and prognosis. In recent years,quantitative proteomics has been widely used in the screening of early diagnostic markers for various diseases including AAD,however,it has stopped at the initial screening and verification stage,and the clinical practical application has made no breakthrough so far.