微球经肝动脉化疗栓塞术对不可切除乙型肝炎性肝癌患者的疗效分析

Microsphere transcatheter arterial chemoembolization for unresectable hepatitis B liver cancer

目的探讨微球经肝动脉化疗栓塞术对不可切除乙型肝炎性肝癌患者的疗效。方法收集2016年11月—2017年11月河北北方学院附属第一医院消化科收治的乙型肝炎性肝癌患者100例,按随机数字表法分为观察组和对照组,每组50例。对照组患者给予常规经肝动脉化疗栓塞术治疗;观察组给予微球经肝动脉化疗栓塞术治疗。比较2组近期临床疗效、肿瘤标志物(AFP、AFP-L3和CA199)水平、生存质量评分和远期临床疗效的情况。结果治疗后,2组患者近期临床疗效、肿瘤标志物(AFP、AFP-L3和CA199)、生存质量评分和远期临床疗效均改善,且观察组近期临床疗效明显高于对照组(58.00%vs.26.00%,χ^2/P=10.509/0.001),观察组患者肿瘤标志物水平明显低于对照组(t/P=17.413/0.000,29.467/0.000,17.429/0.000),观察组生存质量评分显著高于对照组(t/P=5.227/0.000),观察组患者6个月、12个月、24个月的生存率均显著高于对照组(χ^2=4.336/0.037、3.934/0.047、4.058/0.044)。结论微球经肝动脉化疗栓塞术对不可切除乙型肝炎性肝癌患者的治疗效果显著,安全性高。

Objective To explore the effect of microsphere chemoembolization via hepatic artery in the treatment of unresectable hepatitis B liver cancer.Methods From November 2016 to November 2017,100 patients with hepatitis B liver cancer were collected from the Digestive Department of the First Affiliated Hospital of Hebei North University.According to the method of random number table,50 cases in each group were divided into observation group and control group.The patients in the control group were treated with conventional transcatheter arterial chemoembolization.The observation group was treated with microsphere chemoembolization via hepatic artery.The short-term clinical efficacy,tumor markers(AFP,AFP-L3 and CA199),quality of life score and long-term clinical efficacy of the two groups were compared.Results After treatment,the short-term clinical efficacy,tumor markers(AFP,AFP-L3 and CA199),quality of life score and long-term clinical efficacy of the two groups were improved,and the short-term clinical efficacy of the observation group was significantly higher than that of the control group(58.00%vs.26.00%,χ^2/P=10.509/0.001)The level of tumor markers in the observation group was significantly lower than that in the control group(t/P=17.413/0.000,29.467/0.000,17.429/0.000).The quality of life score in the observation group was significantly higher than that in the control group(t/P=5.227/0.000).The survival rate of the observation group at 6,12 and 24 months was significantly higher than that in the control group(χ^2/P=4.336/0.037,3.934/0.047,4.058/0.044).Conclusion Microsphere chemoembolization via hepatic artery has a significant effect and high safety in the treatment of unresectable hepatitis B liver cancer.