苍术麻黄汤及其组成成分在血脂异常治疗中的研究进展

Clinical research progress of Cangzhumahuang decoction and its components in the treatment of dyslipidemia

血脂异常是冠状动脉粥样硬化性心脏病和脑卒中等心脑血管疾病的重要独立危险因素。现代医学治疗血脂异常首选他汀类药物,但其在肌病、肝脏损伤、新发糖尿病等方面仍有明确的不良反应发生。中医药在防治血脂异常方面具有独特的用药特色和潜在优势。中医认为血脂异常多以湿浊、痰浊、血浊为患。苍术麻黄汤为国家名老中医许公岩根据“湿家理脾为要”的思想指导创制而成。文章就苍术麻黄汤在调脂治疗中的机制、相关临床和实验进展进行综述,以期对苍术麻黄汤及其组成成分在临床调脂治疗中的应用提供循证医学依据。

Dyslipidemia is an important independent risk factor for cardiovascular and cerebrovascular diseases in coronary atherosclerotic heart disease and stroke.In modern medicine,statins are the first choice for the treatment of dyslipidemia,but there are still clear adverse reactions in myopathy,liver,and new-onset diabetes.Chinese medicine has unique medication characteristics and potential advantages in preventing and treating dyslipidemia.Chinese medicine believes that abnormal blood lipids are mostly caused by wet turbidity,phlegm and blood turbidity.Cangzhumahuang decoction was created by Mr.Xu Gongyan,a well-known national doctor of traditional Chinese medicine,under the ideological guidance of"wet the house to manage the spleen".This article reviews the etiology and pathogenesis,related clinical and experimental progress of Cangzhumahuang decoction in lipid-lowering therapy,in order to provide evidence-based medical evidence for the study of Cangzhumahuang decoction and its components in clinical lipid-lowering therapy.