普萘洛尔联合甲巯咪唑治疗甲亢的临床效果评价

Clinical Evaluation of Propranolol Combined with Methimazole in the Treatment of Hyperthyroidism

目的:研究甲亢患者实施普萘洛尔与甲巯咪唑联合治疗的临床效果。方法:选择62例我院门诊所收治的甲亢患者,2015年11月至2019年5月作为本研究的时间范围,采用随机数字表法将其分为实验组与参照组,各为31例。其中甲巯咪唑为参照组治疗措施,普萘洛尔与甲巯咪.唑为实.验组治疗方法,对比2组患者治疗前后相关指标及药物.不良反应。结果:甲亢患者头痛、皮肤瘙痒、关节疼痛等不良反应发生率(1290%、968%)未见差异性,治疗前相关指标无明显差异性(P>005),实.验组促甲状腺激素高于参照组,同参照组相比,实验组血清游离甲状腺素、血清游离三碘甲腺原氨酸水平较低,组间差异性水平较高(P<005)。结论:甲亢患者通过普萘洛尔与甲巯咪唑联合治疗效果确切,能够有效改善患者甲状腺相激素水平,且药物安全性水平较高。

Objective: To study the clinical effect of propranolol combined with methimidazole in patients with hyperthyroidism. Methods: A total of 62 patients with hyperthyroidism admitted to the outpatient department of our hospital from November 2015 to May 2019 were selected as the time range of this study. Methimidazole was used as the control group, and propranolol and methimidazole were used as the experimental group. Relevant indicators and adverse drug reactions before and after treatment were compared between the two groups. Results: Hyperthyroidism patients with headache, itchy skin, incidence of adverse reactions such as joint pain(12.90%, 9.68%) no difference, related indicators no significant difference before treatment(P>0.05), thyroid stimulating hormone is higher than the control group, while compared with control group, experimental group serum free thyroxine and serum free iodine original amino acid level is low, a gland group differences between higher levels(P<0.05). Conclusion: The combined treatment of propranolol and methimidazole in patients with hyperthyroidism is effective and can effectively improve the level of thyroid hormone in patients, and the level of drug safety is high.