左旋甲状腺素早期治疗对妊娠合并亚临床甲状腺功能减退症患者妊娠结局的影响

Effect of Early Treatment of Levothyroxine on Pregnancy Outcome in Patients with Subclinical Hypothyroidism

目的:对妊娠期应用左旋甲状腺素早期治疗甲状腺功能减退症对妊娠结局的影响进行研究。方法:本次研究主要将56例妊娠合并亚临床甲状腺功能减退症患者作为研究对象,选取时间段为2016年1月至2019年7月,随机分组后,研究组28例患者采用左旋甲状腺素进行治疗,对照组28例患者未采用药物治疗。之后对两组患者的并发症情况、妊.娠结局和婴幼儿发.育情况等进行对比。结果.:研究组患者妊娠期各种并发症发生概率均显著低于对照组,且研究组患者的自然分娩率为8214%,对照组为5357%,组I间差异显著(P<005),I在婴幼儿发育情况方面,主要是对两组婴幼儿.发育状况(6个月)进行对比,发现研究组婴幼儿的精神运动发育指数(PD)和智力发育指数(MD)均显著高于对照组,差异具备统计学意义(P<005)。结论:对于妊娠合并亚临床甲状腺功能减退症患者,通过左旋甲状腺素早期治疗,不仅有助于提升患者的自然分娩率,同时还能降低各种并发症发生概率,促进了婴幼儿的健康发育,临床推广价值较高。

Objective: The effect of early treatment of hypothyroidism with levothyroxine on pregnancy outcome was studied. Methods: 56 cases of pregnancy complicated with subclinical hypothyroidism were selected from January 2016 to July 2019. After random grouping, 28 patients in the study group were treated with levothyroxine, while 28 patients in the control group were not treated with drugs. After that, the complications, pregnancy outcome and infant development of the two groups were compared. Results: The probability of complications during pregnancy in the study group was significantly lower. In the control group, the natural delivery rate of the study group was 82.14%, the control group was 53.57%, and the difference between the groups was significant(P<0.05). In terms of infant development, the development status of two groups(6 months)was mainly compared. Conclusion: In the patients with subclinical hypothyroidism, the early treatment of L-thyroxine can not only improve the rate of natural delivery, but also reduce variouscomplications. The birth probability promotes the healthy development of infants and young children, and the clinical promotion value is high.