综合护理在HIV并HBV患者行替诺福韦联合拉米夫定抗病毒治疗中的应用价值

Application Value of Comprehensive Nursing in Anti-viral Therapy of Tenofovir Combined with Lamivudine in Patients with HIV and HBV Infection

目的:探讨综合护理在人类免疫缺陷病毒(HIV)合并乙型肝炎病毒(HBV)患者行替诺福韦联合拉米夫定抗病毒治疗中的应用价值。方法:从本院2017年8月至2019年5月收治的行替诺福韦联合拉米夫定抗病毒治疗的HIV并HBV患者中选取48例作为研究对象,采用数字盲选法,划分为Ⅰ组(n=24,常规护理)和Ⅱ组(n=24,综合护理),对比两组CD4+淋巴细胞水平、血清学转换、护理满意度。结果:实施综合护理后,Ⅱ组患者CD4+淋巴细胞水平明显比Ⅰ组高;经护理,Ⅱ组患者血清转换率明显比Ⅰ组高;Ⅱ组患者的焦虑自评量表(SAS)和抑郁自评量表(SDS)评分均比Ⅰ组低。两组比较差异显著(P<0.05)。结论:在行替诺福韦联合拉米夫定抗病毒治疗中采用综合护理模式,HIV并HBV患者CD4+淋巴细胞水平、血清转换率等明显提高,使患者的焦虑、抑郁等负性情绪得到了有效缓解。

Objective:To explore the application value of comprehensive nursing in anti-viral therapy of tenofovir combined with lamivudine in patients with HIV and HBV infection.Methods:In our hospital between August 2017 and May 2019 were rows of tenofovir combined lamivudine antiviral treatment in patients with HIV and HBV from 48 cases as the research object,adopting digital blind method,divided intoⅠgroup(n=24,routine nursing)andⅡgroup(n=24,comprehensive care),compared two groups of CD4+lymphocytes level,seroconversion,nursing satisfaction.Results:After comprehensive nursing,level of CD4+lymphocytes in patients withⅡgroup was obviously higher thanⅠgroup;Patients serum conversion rate after nursing,Ⅱgroup was obviously higher thanⅠgroup;Ⅱgroup of patients with SAS,SDS scores were lower thanⅠgroup.The difference between the two groups was significant(P<0.05).Conclusion:The comprehensive nursing mode adopted in the antiviral treatment of tenofovir combined with lamivudine significantly improved CD4+lymphocyte level and serum conversion rate in patients with HIV and HBV,effectively alleviated the negative emotions such as anxiety and depression.