基于“心肾相交”理论探讨维生素D防治心肾综合征的潜在靶点

To Explore the Potential Targets of Vitamin D in the Prevention and Treatment of Cardiorenal Syndrome Based on the Theory of “Intersection of Heart and Kidney”

心肾综合征(cardio-renalsyndrome, CRS)定义为心脏和肾疾病,其中一个器官的急性或慢性功能障碍可能导致另一个器官的急性或慢性功能不全,最终加速心脏和肾脏功能的共同损害和衰竭。中医学对心肾生理功能与病理变化的认识较早,虽无CRS之名,却明确提出"心肾相交"理论;故基于此传统理论,从心肾相交的思维论治CRS具有一定理论依据,并能为该疾病的治疗提供新的思路。中医学"心"的现代生物学本质已被证明与维生素D(vitaminD, VD)存在联系,而"肾"的部分脏腑功能失常被认为与维生素D缺乏有关。最新研究发现,维生素D不仅对心血管系统疾病有重要影响,而且与肾脏疾病的发生发展密切相关。本文基于"心肾相交"的中医理论,探讨维生素D防治CRS的潜在靶点,以期为该疾病的防治提供科学论据。

Cardio-Renal Syndrome(CRS) is defined as heart and kidney disease. Acute or chronic dysfunction appeared in one organ will lead to the other organ appeared the same situation, which will be accelerated damage and failure for both heart and kidney functions. In theory of traditional Chinese medicine, the physiological function and pathological changes of heart and kidney had been recognized earlier. Although there was no name of CRS, the theory of "intersection of heart and kidney" was clearly given. Based on the traditional theory, the treatment of CRS from the perspective of the intersection of heart and kidney has certain theoretical basis, and can provide new ideas for treatment of this disease.The modern biological nature of the heart in traditional Chinese medicine has been linked to Vitamin D, and the dysfunction of the kidneys has been linked to Vitamin D deficiency. Recent research results showed that vitamin D not only plays an important role in cardiovascular disease, but also in the development of kidney disease. Based on the traditional Chinese medicine theory of "heart-kidney intersection". In this paper, the potential targets of vitamin D for prevention and treatment of CRS were discussed to provide scientific evidence for prevention and treatment of this disease.