化肝煎加味治疗肝胃郁热型胃食管返流病临床观察

Clinical Analysis of 50 Cases of Gastroesophageal Reflux Disease Treated by Huagan Decoction

目的研究化肝煎加味治疗肝胃郁热型胃食管返流病的临床疗效。方法选择在武进中医医院门诊接受治疗的胃食管返流病患者,根据其来院先后顺序对其进行分组,将50例胃食管返流病患者进行分组,主要包括两组,其中观察组实施化肝煎加味治疗;对照组实施常规西药治疗,将两组效果进行对比。结果观察组治疗后反酸嗳气(0.83±0.02)分、胸脘嘈热(0.94±0.23)分、口干口苦(0.81±0.04)分、性急善郁(0.55±0.01)分与对照组比较,具有统计学意义(P<0.05)。观察组25例和对照组25例胃食管返流病患者治疗效果相比较,前者更高(P<0.05)。观察组胃食管返流病治疗后胃动素(304.56±1.28)pg/mL、胃泌素(139.45±1.24)pg/mL均高于对照组食管返流病患者治疗后胃动素(273.44±1.12)pg/mL、胃泌素(109.22±1.92)pg/mL,具有统计学意义(P<0.05)。观察组胃食管返流病不良反应发生率(4.00%,1/25)低于对照组不良反应发生率(28.00%,24/25),具有统计学意义(P<0.05)。观察组胃食管返流病焦虑(6.56±1.02)分、抑郁(5.56±1.33)分均低于对照组焦虑(13.09±1.25)分、抑郁(14.55±1.02)分,具有统计学意义(P<0.05)。观察组胃食管返流病患者症状缓解情况所占比为(96.00%,24/25)、胃食管壁愈合情况所占比(92.00%,23/25)、PH缓解情况所占比(96.00%,24/25)均高于对照组症状缓解情况所占比为(68.00%,17/25)、胃食管壁愈合情况所占比(48.00%,12/25)、PH缓解情况所占比(60.00%,15/25),具有统计学意义(P<0.05)。结论化肝煎加味治疗肝胃郁热型胃食管返流病临床疗效显著,值得推广。

Objective To study the clinical efficacy of Huagan decoction in the treatment of 50 cases of gastroesophageal reflux disease of liver and stomach.Methods Patients with gastroesophageal reflux disease who were treated in the outpatient department of Wujin Traditional Chinese Medicine Hospital were selected as the subjects of this study.According to their order of hospitalization,50 patients with gastroesophageal reflux disease were divided into two groups,including two groups.The observation group and the implementation of Huagan decoction treatment;the control group,the implementation of conventional Western medicine treatment,the two groups of effects were compared.Results In the observation group,patients with gastroesophageal reflux disease were treated with acid reflux(0.83±0.02),chest fever(0.94±0.23),dry mouth(0.81±0.04),and acute stagnation(0.55±0.01)was compared with the control group and had a difference(P<0.05).The therapeutic effect of 25 patients in the observation group and 25 patients with gastroesophageal reflux disease was higher in the former group(P<0.05).After treatment,patients with gastroesophageal reflux disease in the observation group were treated with motilin(304.56±1.28)pg/ml and gastrin(139.45±1.24)pg/mL,which were higher than those in the control group with esophageal reflux disease(273.44±1.12)pg/mL,gastrin(109.22±1.92)pg/mL,with a difference(P<0.05).The incidence of adverse reactions in patients with gastroesophageal reflux disease was 4.00%in the observation group and 28.00%in the control group,which was different(P<0.05).The scores of anxiety(6.56±1.02)and depression(5.56±1.33)in the observation group were lower than those in the control group(13.09±1.25)and depression(14.55±1.02),which were different(P<0.05).In the observation group,the proportion of symptom relief in patients with gastroesophageal reflux disease was(96.00%,24/25),the proportion of gastroesophageal wall healing was(92.00%,23/25),and the proportion of PH remission was(96.00%,24/25),which was higher than that of the control group(68.00%,17/25),the gastroesophageal wall healing rate accounted for(48.00%,12/25),and the PH relief situation accounted for(60.00%,15/25),with a difference(P<0.05).Conclusion The clinical efficacy of Huagan decoction in treating 50 cases of gastroesophageal reflux disease of liver and stomach stagnation is very significant.