麻黄附子细辛汤联合常规疗法治疗感染后咳嗽的临床研究

Clinical Research of Ephedra Aconitum Asarum Decoction in Treatment for Post-Infectious Cough

目的探讨麻黄附子细辛汤治疗感染后咳嗽的临床效果。方法选取漯河市郾城区惠生堂门诊部和河南省漯河市第三人民医院呼吸内科于2017年5月—2018年10月诊治的感染后咳嗽患者240例,采用随机数字表法分为两组,对照组患者120例实施常规治疗(退热、吸氧、补液等),观察组患者120例联用麻黄附子细辛汤(紫苏子9 g,射干9 g,地龙9 g,炙麻黄6 g,细辛6 g)治疗,于治疗前后行生化指标(C反应蛋白、白细胞计数、白细胞介素-4)检测和症状(咳嗽、喘息、咳痰、哮鸣音)评分,比较两组患者的症状(咳嗽、喘息、咳痰、哮鸣音)改善时间、临床效果(显效、有效、无效、总有效)、不良反应情况(恶心呕吐、头晕头痛、胃肠道反应)。结果两组治疗后C反应蛋白、白细胞计数、白细胞介素-4、症状评分(咳嗽、喘息、咳痰、哮鸣音)较治疗前显著降低(P<0.05)。观察组治疗后C反应蛋白、白细胞计数、白细胞介素-4、症状评分(咳嗽、喘息、咳痰、哮鸣音)低于对照组(P<0.05)。观察组症状改善时间(咳嗽、喘息、咳痰、哮鸣音)早于对照组(P<0.05)。观察组总有效率(99.2%,119/120)高于对照组(90.0%,108/120)(P<0.05)。结论麻黄附子细辛汤治疗感染后咳嗽的效果显著,可缩短治疗时间并改善病症,值得临床推广使用。

Objective To investigate clinical effect of ephedra aconitum asarum decoction in treatment for post-infectious cough.Methods 240 patients with post-infectious cough were selected in Luohe City Nuocheng District Huishengtang Clinic and department of Respiratory Medicine in Henan Province Luohe City Third People's Hospital from May 2017 to October 2018,who were divided into two groups by random number table.120 patients received routine treatment(antipyretic,oxygen inhalation,rehydration,etc.)as control group.120 patients combined with ephedra aconitum asarum decoction(Perilla frutescens 9 g,Shegan 9 g,Dilong 9 g,Roasted ephedra 6 g,Asarum 6 g)as observation group.Biochemical tests(C-reactive protein,white blood cell count,interleukin-4)and symptom(cough,wheeze,expectoration,wheezing)scores were performed before and after treatment.Improvement time of symptoms(cough,wheeze,expectoration,wheezing),clinical effect(significant,effective,ineffective,total effective),adverse reactions(nausea and vomiting,dizziness and headache,gastrointestinal reactions)were compared between two groups.Results C-reactive protein,white blood cell count,interleukin-4,symptom scores(cough,wheezing,sputum,wheezing)decreased significantly in two groups after treatment(P<0.05).C-reactive protein,white blood cell count,interleukin-4,symptom scores(cough,wheezing,sputum,wheezing)in observation group were lower than control group after treatment(P<0.05).Improvement time of symptoms(cough,wheeze,sputum and wheezing)in observation group were earlier than control group(P<0.05).Total effective rate in observation group(99.2%,119/120)was higher than control group(90.0%,108/120),while difference was statistically significant(P<0.05).Conclusion Ephedra aconitum asarum decoction has significant effect in treatment for post-infectious cough,which can shorten treatment time and improve symptoms.That is worthy of clinical application.