16例牙源性腺样瘤临床病理学特点及鉴别诊断

Clinicopathological features and differential diagnosis of adenomatoid odontogenic tumor

目的探讨牙源性腺样瘤(AOT)的临床病理学特点及鉴别诊断。方法收集郑州大学第一附属医院2012-2018年诊断的牙源性腺样瘤16例,进行归纳分析。结果 16例AOT患者发病年龄为2~73岁,中位年龄约15岁。男女比例约1∶3,8例发生于上颌骨,8例发生于下颌骨。影像学多表现为囊性低密度影,内含牙齿。组织学上肿瘤细胞排列成大小不等的结节,可见玫瑰花样、腺管状等排列,还可见嗜酸性小滴及小灶钙化;肿瘤细胞p63(+),间质vimentin(+),Ki-67增殖指数<5%。结论 AOT在临床表现、影像学表现、病理学形态及免疫组化等方面有独立的特点。

Objective To investigate the clinicopathological features and differential diagnosis of adenomatoid odontogenic tumor. Methods Sixteen cases of odontogenic adenoid tumors diagnosed in the Department of Pathology the First Affiliated Hospital of Zhengzhou University from 2012 to 2018 were collected and analyzed. Results The age of onset of 16 cases of adenomatoid odontogenic tumor was 2 ~ 73 years old with a median age of 15 years. The male to female ratio was 1 ∶ 3;8 cases occurred in the maxilla,and 8 cases occurred in the mandible. Most of the imaging findings were cystic low-density images with teeth. Histological characteristics Tumor cells were arranged in nodules of different sizes.Roses,glandular tubes,etc. were seen. Eosinophilic droplets and small lesions were also seen. Tumor cells were positive for P63,and interstitial expression was vimentin,Ki-67 < 5%. Conclusion Adenomatoid odontogenic tumor has independent characteristics in clinical manifestations, imaging findings, pathological morphology and immunohistochemistry.