摘要
Summary of main observation and conclusion Tetrahydroisoquinoline derivatives are useful synthetic intermediates,which play an important role in the preparation of natural products,pharmaceuticals and other materials.Herein,we report an unprecedented redox-neutral aza-benzoin protocol to construct such scaffold.Upon exposure of tetrahydroisoquinolines to aromatic aldehydes in the prese nee of an NHC catalyst,the C-l acylated tetra hydroisoquinolines were obtained in moderate to good yields.
基金
the National Natural Science Foundation of China(Nos.21672121 and 21871160)
the"Thousand Plan"Youth Program of China,Tsinghua University,the Bayer Investigator Fellowship,and the Fellowship of Tsinghua-Peking Centre for Life Sciences(CLS).
