血清白蛋白和肌酐水平对于肌萎缩性侧索硬化症患者生存预期的预测价值

The prediction value of serum albumin and creatinine in patients with amyotrophic lateral sclerosis

目的评估肌萎缩性侧索硬化症(ALS)患者血清标志物与生存预期的关系。方法选择3年内诊治的30例ALS患者,比较生存组和死亡组的临床资料和血清生化检测水平,探究ALS患者生存预后的影响因素,评价血清标志物在预测ALS不良预后中的效能。结果生存组患者的ALSFRS-R总分、高密度脂蛋白、血清白蛋白和肌酐水平均显著低于死亡组(P=0.000)。血清白蛋白及血清肌酐是ALS患者生存预后的独立保护因素(P<0.05)。血清白蛋白和肌酐预测ALS不良预后的AUC差异无统计学意义(P>0.05)。血清白蛋白和肌酐在预测ALS不良预后的准确率、灵敏度、特异度和阳性预测值均较高。结论血清白蛋白和肌酐水平是ALS患者生存预后的独立保护因素,检测血清白蛋白和肌酐对ALS不良预后具有较高的预测效能。

Objective To evaluate the prediction value of serum albumin and creatinine in patients with amyotrophic lateral sclerosis.Methods Thirty ALS patients in three years were performed.The clinical information and the levels of serum albumin and creatinine of alive group and dead group were comparatively analyzed.The influencing factors of survival and the value of serum albumin and creatinine in outcome measures prediction were performed.Results The total scores of ALSFRS-R,HDL,serum albumin and creatinine in the survival group were significantly lower than those in the death group(P=0.000).Serum albumin and serum creatinine are independent protective factors for survival prognosis in patients with ALS(P<0.05).Serum albumin and creatinine had no statistical significance on the difference in AUC for predicting poor prognosis in ALS(P>0.05).Serum albumin and creatinine have higher accuracy,sensitivity,specificity and positive predictive value in predicting the poor prognosis of ALS.Conclusion Serum albumin and creatinine were independent protective factors for the ALS outcome measures,and the detection of serum albumin and creatinine has a high predictive effect on the prognosis of ALS.