硫酸镁联合硝苯地平联合治疗对妊高症患者血清hs-CRP、sVCAM-1水平的影响

Effect of magnesium sulfate combined with nifedipine on serum hs-CRP and sVCAM-1 levels in patients with pregnancy induced hypertension

目的:研究硫酸镁联合硝苯地平治疗妊高症疗效。方法:选本院妊高症患者140例,随机均分成两组。对照组单纯采用硫酸镁治疗;研究组采用硫酸镁和硝苯地平联合治疗。比较两组患者治疗结局。结果:两组患者hs-CRP、sVCAM-1的水平均有一定程度的改善,但研究组改善程度优于对照组;两组患者血压水平均有不同程度的改善,但研究组患者DBPV、SBPV的水平改善更明显差异显著,P<0.05。结论:硫酸镁以及硝苯地平联合应用治疗妊高症能够显著降低患hs-CRP、sVCAM-1的水平,降低患者的血压,对妊高症的治疗与控制有显著的积极意义,是一种优秀的临床用药治疗方案。

Objective:To study the efficacy of magnesium sulfate combined with nifedipine in the treatment of pregnancy induced hypertension.Methods:A total of 140 patients with pregnancy-induced hypertension were randomly divided into two groups.Control group:treatment with magnesium sulfate alone;experimental group:combined treatment with magnesium sulfate and nifedipine.The treatment outcomes of the two groups were compared.Results:The levels of hs-CRP and sVCAM-1 in the two groups were improved to some extent,but the improvement of the experimental group was better than that of the control group.The blood pressure levels of the two groups were improved to some extent,but the DBPV and SBPV of the experimental group were The level improvement was significantly more significant,P<0.05.Conclusion:The combination of magnesium sulfate and nifedipine in the treatment of pregnancy-induced hypertension can significantly reduce the levels of hs-CRP and sVCAM-1,lower the blood pressure of patients,and has a significant positive effect on the treatment and control of pregnancy-induced hypertension.It is an excellent Clinical medication regimen.