摘要
血管紧张素转换酶2(ACE2)是SARS病毒(SARS-CoV)、新型冠状病毒(SARS-CoV-2)感染机体的主要受体,也是肾素-血管紧张素-醛固酮系统的主要成员之一。ACE2对多种心血管疾病具有保护作用,SARS-CoV-2可以降低机体ACE2的表达,这可能是新型冠状病毒肺炎(COVID-19)后期产生心血管并发症的原因之一。本文总结了ACE2在多种心血管疾病发病过程中的作用及其机制,希望为新型冠状病毒肺炎(COVID-19)的治疗提供新的思路。
Angiotensin-converting enzyme 2(ACE2)is the receptor for SARS-CoV and SARS-CoV-2(severe acute respiratory syndrom coronavirus 2)viruses,and it is also one of the main family members of renin-angiotensin-aldosterone system.ACE2 has a protective effect on cardiovascular diseases and inhibits the development of cardiovascular diseases.SARS-CoV-2 reduces the expression of ACE2 of host,which may be one of the reasons for cardiovascular complications in the later stage of coronavirus disease 2019(COVID-19).Thus,the role and mechanism of ACE2 in the development of cardiovascular diseases were summarized in this article in order to provide potential stratigy development for the treatment of COVID-19.
作者
焦晓璐
秦彦文
JIAO Xiao-lu;QIN Yan-wen(the Key Laboratory of Upper Airway Dysfunction-related Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing 100029, China)
出处
《基础医学与临床》
CSCD
2020年第5期701-706,共6页
Basic and Clinical Medicine
基金
国家自然科学基金(81970224,81670331)
北京市自然科学基金(7192030)。
