血管紧张素转换酶2在人类高致病性冠状病毒肺炎中作用的研究进展

Research progress of the role of angiotensin-converting enzyme 2(ACE2)in the highly pathogenic human coronavirus pneumonia

2019年底爆发的新型冠状病毒(SARS-CoV-2)是一种新发现的人类高致病性冠状病毒。据调查其和严重急性呼吸综合征冠状病毒(SARS-CoV)具有一定的相似性。血管紧张素转换酶2(ACE2)是SARS-CoV感染细胞的受体,并且可能也是SARS-CoV-2的功能受体。目前发现SARS-CoV可通过刺突蛋白与ACE2结合侵入细胞,同时ACE2在炎症性肺疾病的病程中也起到了重要作用。因此ACE2在SARS及新型冠状病毒肺炎(COVID-19)中的可能作用值得讨论。本文简要总结了ACE2在SARS中的作用,讨论了ACE2在COVID-19中可能的作用及感染其他器官的潜在风险,最后针对ACE2的功能探讨了SARS的治疗策略,以期为临床治疗COVID-19提供借鉴和启示。

A novel coronavirus(SARS-CoV-2)that broke out at the end of 2019 is a newly discovered highly pathogenic human coronavirus and has some similarities with severe acute respiratory syndrome coronavirus(SARSCoV).Angiotensin-converting enzyme 2(ACE2)is the receptor for infected cells by SARS-CoV.SARS-CoV can invade cells by binding to ACE2 through the spike protein and SARS-CoV-2 may also infect cells through ACE2.Meanwhile,ACE2 also plays an important role in the course of pneumonia.Therefore the possible role of ACE2 in SARS and coronavirus disease 2019(COVID-19)is worth discussing.This paper briefly summarized the role of ACE2 in SARS,and discussed the possible function of ACE2 in COVID-19 and potential risk of infection with other organs.At last,the function of ACE2 was explored for possible treatment strategies for SARS.It is hoped to provide ideas and theoretical support for clinical treatment of COVID-19.