内皮祖细胞在防治糖尿病血管并发症的应用前景

Application prospect of endothelial progenitor cells on prevention and treatment of diabetes-related cardiovascular diseases

我国糖尿病的发病率和死亡率呈逐年上升趋势,继发于糖尿病的血管并发症已成为糖尿病患者死亡的主要原因。内皮祖细胞(endothelial progenitor cells,EPCs)促进血管新生和修复血管损伤,EPCs耗竭和功能障碍导致糖尿病血管病变的发生发展。本文就EPCs对治疗糖尿病血管并发症的作用进行综述。EPCs是治疗糖尿病心血管病的一种新手段。EPCs移植治疗目前已经在动物实验水平证实有效,但仍缺乏大样本临床试验来验证EPCs移植治疗对糖尿病血管病变患者的有效性和安全性。适量饮酒、使用雌激素和他汀类药物、运动等,均可以刺激EPCs动员、增殖、迁移,并促血管新生,从而对治疗糖尿病心血管疾病具有重要意义。

The incidence and mortality of diabetes in China are increasing year by year,and vascular complications secondary to diabetes have proved to be the main cause of death in diabetic patients.Endothelial progenitor cells(EPCs)can promote angiogenesis and repair impaired vessels,while EPCs depletion and dysfunction lead to the development of diabetic angiopathy.This article reviews the role of EPCs in treatment and prevention of diabetes-related cardiovascular diseases.EPCs provide a new approach to the treatment of diabetes-induced cardiovascular diseases.Although positive effects were documented by animal study both in vivo and vitro,clinical trials with large sample are still required to verify the efficiency and safety of EPCs transplantation therapy in patients with diabetes-induced cardiovascular diseases.Moderate alcohol consumption,use of estrogen and stains,as well as physical exercise etc.can stimulate EPCs to mobilize,proliferate and migrate,they can also promote angiogenesis,which is of great significance for the treatment of diabetes induced cardiovascular diseases.