SDF-1促进糖尿病溃疡创面血管新生

SDF-1 promotes diabetic ulcer wound angiogenesis

随着糖尿病发病率的逐年增长,糖尿病溃疡的关注度也在不断攀升。近年研究发现,基质细胞衍生因子-1(stromal cell derived factor-1,SDF-1)可以通过动员多种细胞因子促进血管新生,在糖尿病溃疡的愈合中发挥重要作用,其靶向治疗为糖尿病足等慢性溃疡治疗提供了新方向。本文主要就SDF-1与糖尿病溃疡创面血管新生的研究作一综述。

As the number of people with diabetes climbs,the attention on diabetic ulcers is also rising.In recent years,the studies have shown that the stromal cell derived factor-1(SDF-1)axis in the migration of transplanted angiogenesis mobilized by varied cytokine plays an important role in the healing of diabetic ulcers,and its target treatment provides a new way to chronic ulcers such as diabetic foot.Researches on SDF-1 and angiogenesis in diabetic ulcer wound are mainly reviewed in this article.