低分子肝素钙治疗肺心病并呼吸衰竭的临床价值研究

Study on clinical value of low-molecular-weight heparin calcium in treating pulmonary heart disease and respiratory failure

目的探讨肺源性心脏病(肺心病)并呼吸衰竭患者运用低分子肝素钙进行治疗的临床应用价值。方法72例肺心病并呼吸衰竭患者,应用随机数字表法分为观察组和对照组,每组36例。对照组患者采取常规治疗,观察组患者在对照组上采用低分子肝素钙治疗。对比两组患者治疗前后动脉血气指标[氧分压(PaO2)、二氧化碳分压(PaCO2)及酸碱度(pH)值]及治疗效果。结果治疗前,两组患者的PaO2、PaCO2、pH值水平比较,差异无统计学意义(P>0.05);治疗后,观察组患者的PaO2(9.36±1.02)kPa明显高于对照组的(7.78±0.98)kPa,PaCO2(6.33±0.97)kPa明显低于对照组的(7.65±1.28)kPa,差异均具有统计学意义(P<0.05);两组患者pH值比较差异无统计学意义(P>0.05)。观察组患者总有效率为97.22%,显著高于对照组的83.33%,差异具有统计学意义(P<0.05)。结论针对肺心病并呼吸衰竭患者运用低分子肝素钙进行治疗,可有效改善患者的血气指标,提高治疗效果,具有较高的临床价值。

Objective To discuss the clinical value of low-molecular-weight heparin calcium in treating pulmonary heart disease and respiratory failure.Methods A total of 72 patients with pulmonary heart disease and respiratory failure were divided into observation group and control group by random number table method,with 36 cases in each group.The control group received conventional therapy,and the observation group received low-molecular-weight heparin calcium on the basis of the control group.The arterial blood gas indexes[oxygen partial pressure(PaO2),partial pressure of carbon dioxide(PaCO2)and pH value]before and after treatment,and therapeutic effect were compared between the two groups.Results Before treatment,there was no statistically significant difference in PaO2,PaCO2 and pH value between the two groups(P>0.05).After treatment,PaO2 of the observation group(9.36±1.02)kPa was obviously higher than that of the control group(7.78±0.98)kPa,and PaCO2(6.33±0.97)kPa was obviously lower than that of the control group(7.65±1.28)kPa,and the difference was statistically significant(P<0.05).There was no statistically significant difference in pH value between the two groups(P>0.05).The total effective rate of the observation group was 97.22%,which was significantly higher than that of the control group 83.33%,and the difference was statistically significant(P<0.05).Conclusion Low-molecular-weight heparin calcium can effectively improve the blood gas index of patients with pulmonary heart disease and respiratory failure,improve their treatment efficiency,and this method contains high clinical value.