摘要
目的探讨艾司洛尔对急性前壁心肌梗死患者冠状动脉(冠脉)介入术中心电图QT离散度(QTd)及恶性室性心律失常的影响。方法60例急性前壁心肌梗死拟行急诊冠脉介入手术患者,采用前瞻、随机对照方法分为治疗组及对照组,各30例。治疗组即刻给予艾司洛尔静脉注射,继之静脉泵入;对照组即刻给予美托洛尔口服。比较两组治疗前后QTd及术中恶性室性心律失常发生情况。结果治疗前,两组患者的QTd比较,差异无统计学意义(P>0.05);治疗后,两组患者的QTd均较本组治疗前降低,且治疗组QTd(39.0±15.5)ms低于对照组的(53.0±14.7)ms,差异均具有统计学意义(P<0.05)。治疗组患者术中恶性室性心律失常发生率10.0%低于对照组的33.3%,差异具有统计学意义(P<0.05)。结论急性前壁心肌梗死患者行冠脉介入治疗术时应用艾司洛尔静脉泵入更能有效降低QTd,减少术中恶性室性心律失常的发生。
Objective To discuss the effect of esmolol on QT dispersion(QTd)and malignant ventricular arrhythmia in patients with acute anterior myocardial infarction.Methods A total of 60 cases of acute anterior myocardial infarction with selected emergency coronary intervention were divided into treatment group and control group by prospective,randomized controlled method,with 30 cases in each group.The treatment group received intravenous esmolol immediately followed by intravenous pumping,and the control group received oral metoprolol immediately.QTd before and after treatment and occurrence of intraoperative malignant ventricular arrhythmia were compared between the two groups.Results Before treatment,there was no statistically significant difference in QTd between the two groups(P>0.05).After treatment,QTd of the two groups were lower than those before treatment of the same group,and QTd of the treatment group(39.0±15.5)ms was lower than that of the control group(53.0±14.7)ms.The difference was statistically significant(P<0.05).The incidence of intraoperative malignant ventricular arrhythmia of the treatment group was 10.0%,which was lower than that of the control group 33.3%,and the difference was statistically significant(P<0.05).Conclusion For patients with acute anterior myocardial infarction,esmolol intravenous infusion during coronary interventional therapy is more effective in reducing QTd and lowering the incidence of intraoperative malignant ventricular arrhythmia.
作者
毕朝晖
BI Zhao-hui(Zibo Central Hospital,Zibo 255000,China)
出处
《中国实用医药》
2020年第11期89-91,共3页
China Practical Medicine
