放射性颌骨坏死的病因学研究进展

Research progress of the etiology of osteoradionecrosis of the jaws

放射性颌骨坏死是头颈部恶性肿瘤放疗最严重和最重要的并发症之一,常导致严重的疼痛、病理性骨折、死骨分离和瘘道形成,严重影响患者的生存质量甚至危及生命。尽管目前已经形成许多关于放射性颌骨坏死发生的理论学说,关于该病的病因及发病机制仍尚不明确,现将关于放射性颌骨坏死病因及发病机制的相关研究作一综述。

Osteoradionecrosis of the jaws(ORNJ)is one of the most serious and important complications of radiotherapy for head and neck cancer,which often leads to severe pain,pathological fracture,sequestration of devitalized bone,and orocutaneous fistulas,and seriously reduces the patients’survival quality and is even life-threatening.Although many theories of how it occurs have been formulated,the exact etiology and pathogenesis of ORNJ are not certain.The purpose of this article is to review and summarize the progress of studies on etiology and pathogenesis of ORNJ.