松果菊苷防晒乳膏剂的制备工艺与质量评价

Preparation and quality evaluation of echinacoside sunscreen cream

目的研究松果菊苷防晒乳膏剂的制备工艺,并对其质量进行评价。方法通过正交试验对松果菊苷防晒乳膏剂基质处方进行优化,优选出最佳处方;通过紫外扫描法建立质量评价标准。结果优选出松果菊苷防晒乳膏剂的最佳处方为松果菊苷5%、硬脂酸10%、单硬脂酸甘油酯5%、液状石蜡5%、白凡士林10%、三乙醇胺4%、氮酮3%、尼泊金乙酯0.1%。按照该处方制备的乳膏剂在最大吸收波长334 nm处的吸光度值相对稳定。结论松果菊苷防晒乳膏剂的制备工艺简单,所得制剂性质稳定,质量可控,测定方法简便、快捷、准确,为后期进一步研究和应用奠定了基础。

Objective To prepare echinacoside sunscreen cream and evaluate its quality.Methods The formulation of echinacoside sunscreen cream base was optimized by orthogonal test.The quality evaluation standard was established by UV scanning.Results The optimal formulation of echinacoside sunblock cream was 5%echinacoside,10%stearic acid,5%glycerin monostearate,5%liquid paraffin,10%white petrolatum,4%triethanolamine,3%azone and 0.1%nipagin.The stability and stable absorbency at the maximum absorption wavelength 334 nm were reached.Conclusion The preparation of echinacoside sunscreen cream is simple,and the quality of the preparation is stable and controllable.The determination is simple,rapid and accurate,laying a foundation for further research and application.