冠心病心脏运动康复的心血管保护机制及临床获益研究进展

Research advances on cardiovascular protection mechanism and clinical benefits of cardiac rehabilitation in coronary heart disease

近年来,随着心脏康复(cardiac rehabilitation,CR)的发展冠心病预后及不良心血管事件得以改善,但以运动为基础的心脏康复干预冠心病心血管保护机制仍未明确。微小核糖核酸(microRNA,miRNAs)是一类内源性的非编码RNA,参与基因转录后表达调控。越来越多研究表明,运动调节心脏及循环中的miRNAs产生心血管保护作用,这进一步验证miRNAs是心血管疾病治疗的潜在靶点,并为评估运动有效性提供潜在生物标志物。本文就近年来运动的心血管保护机制、运动调节miRNAs产生的心血管作用及冠心病实施CR的临床获益做一综述,为研究及治疗冠心病提供新思路。

In recent years,with the development of Cardiac Rehabilitation(CR),the prognosis of coronary heart disease and adverse cardiovascular events have improved,but the cardiovascular protection mechanism for coronary heart disease intervention based on exercise-based cardiac rehabilitation remains unclear. MicroRNAs(miRNAs)are a class of endogenous non-coding RNAs that participate in the regulation of gene expression after transcription. More and more studies show that exercise regulates the cardiovascular effects of miRNAs in the heart and circulation,which further validates miRNAs as potential targets for cardiovascular disease treatment and provides potential biomarkers for assessing the effectiveness of exercise. In this article,the cardiovascular protection mechanisms of exercise in recent years,the cardiovascular effects of exercise-regulated miRNAs,and the clinical benefits of CR are discussed,aiming to provide new ideas for theresearch and treatment of coronary heart disease.