摘要
目的综述古籍中对白芍镇痛功效的记载,以及近年来阐述白芍镇痛功效与机理的研究,为其临床应用和效应机制的深入研究提供参考依据。方法查阅古籍和近年有关白芍镇痛功效的文献报道,并进行归纳、分析和总结。结果历代诸多医家及著作均有对白芍镇痛功效与主治的详细描述。临床研究证实白芍方药及其提取物白芍总苷对于腰腿痛、内脏痛、头痛、癌性疼痛等痛证疗效确切,副作用少。基础实验表明,白芍及其提取物可通过调节前列腺素、相关受体和信号转导通路等多种途径发挥镇痛作用,还可拮抗吗啡等西药镇痛耐受,与甘草、川乌、马钱子等中药配伍后,还具有一定的增效减毒作用。结论白芍在治疗多种痛证方面疗效显著,机制复杂,具有很好的发展潜力和很高的研究价值,有待进一步探索发掘。
Objective This paper summarizes the records of the analgesic effect of Radix paeoniae alba in ancient books and the research on the analgesic effect and mechanism of Paeonia lactiflora in recent years,so as to provide a reference basis for the further study of its clinical application and mechanism.Methods The ancient books and the literature reports about the analgesic effect of Paeonia lactiflora in recent years were consulted,analyzed and summarized.Results Many doctors and works in the past dynasties have a detailed description of its analgesic efficacy and application.Modern clinical studies have confirmed that Radix paeoniae alba decotion and its extracts total glucosides of paeony has definite effect and less side effects for low back and leg pain,visceral pain,headache,cancer pain and so on.Basic experiments show that Radix paeoniae alba and its extract can exert analgesic effect by regulating prostaglandins,related receptors and signal pathways.They can also antagonize the analgesic tolerance of morphine and other western drugs,and the combination with liquorice,monkshood,nuces vomicae and other traditional Chinese medicine has a certain synergistic and detoxification effect.Conclusions Radix paeoniae alba is effective in the treatment of a variety of pain syndromes and the mechanism is complex.It has a good development potential and high research value,which needs to be further explored.
作者
代倩倩
夏欢
夏桂阳
商洪才
石兆峰
黄雨丝
李心怡
林生
田贵华
Dai Qianqian;Xia Huan;Xia Guiyang;Shang Hongcai;Shi Zhaofeng;Huang Yusi;Li Xinyi;Lin Sheng;Tian Guihua(Key Laboratory of Chinese Medicine of Ministry of Education and Beijing Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine,Beijing 100700,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2020年第1期39-46,共8页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
北京中医药大学东直门医院2018青苗人才计划(DZMYS-201801),负责人:田贵华
国家自然科学基金委员会面上项目(81674050):电针对CPSP大鼠星形胶质细胞介导的Wnt/β-catenin信号通路调控作用,负责人:田贵华.
关键词
白芍
白芍总苷
镇痛功效
镇痛机理
研究进展
Radix paeoniae alba
total glucosides of paeony
analgesic effect
analgesic mechanism
research progress