摘要
目的采用数据挖掘的方法研究中医药治疗子宫腺肌病(Adenomyosis,AM)的用药规律。方法收集妇科彩超诊断为子宫腺肌病的患者3768例,处方数8986个,其中中药信息201242条,影像学资料4322条,使用的中药362味,使用复杂网络软件Liquorice系统进行挖掘分析。结果治疗子宫腺肌病的中药使用频次>2000的中药35味,核心处方复杂网络图中的药物有当归、白芍、川芎、醋延胡索、醋香附、蒲黄、炙甘草、党参,得到3层核心药物加减配伍子网络图。结论运用复杂网络分析的方法,反映了真实世界中医对子宫腺肌病的诊疗思路及用药规律。治疗AM应在活血化瘀的总前提下,佐以理气止痛,益气补血。寒凝血瘀者温经散寒,热灼血瘀者清热解毒,气滞血瘀者行气活血,正气虚弱者补肾益气。
Objective To study the rule of Chinese medicine in the treatment of adenomyosis(AM)by data mining.Methods A total of 3768 patients with adenomyosis diagnosed by gynecological color ultrasound were collected,and the number of prescriptions was 8,986,including 201242 Chinese medicine information,4322 imaging materials,and 362 flavors of traditional Chinese medicine.The complex network software Liquorice system was used for excavation analysis.Results The traditional Chinese medicine for treating adenomyosis used 35 flavors of traditional Chinese medicine with a frequency of>2000.The drugs in the complex network diagram of the core prescription include Radix Angelicae Sinensis,Radix Paeoniae Alba,Rhizoma Ligustici Chuanxiong,vinegar processed Rhizoma Corydalis,vinegar processed Rhizoma Cyperi,Pollen Typhae,Radix Glycyrrhizae and Radix Codonopsis.3-layer core drug addition and subtraction sub-network diagram.Conclusion The method of complex network analysis reflects the diagnosis and treatment of adenomyosis and the law of medication in real world Chinese medicine.Treatment of AM should be based on the general premise of promoting blood circulation and removing blood stasis,accompanied by qi and pain,qi and blood.Dispelling cold with warm medicine,clearing heat with cold medicine,useing blood medicine to promote blood circulation,tonicing with nourishing medicine.
作者
于航
师伟
王怡斐
赵晓晓
徐丽
李伟
张润顺
李思毅
Yu Hang;Shi Wei;Wang Yifei;Zhao Xiaoxiao;Xu Li;Li Wei;Zhang Runshun;Li Siyi(College of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Jinan 250014,China;Department of Gynecology,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,China;Department of Cardiology,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,China;First Clinical Medical College,Shandong University of Traditional Chinese Medicine,Jinan 250014,China;Department of Traditional Chinese Medicine,Shandong Provincial Hospital Affiliated to Shandong University,Jinan 250021,China;Department of Nephrology,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,China;Department of Spleen and Stomach,China Academy of Chinese Medical Sciences Guang'anmen Hospital,Beijing 100053,China;College of Acupuncture and Massage,Shannxi University of Traditional Chinese Medicine,Xianyang 712046,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2020年第1期169-175,共7页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
山东省科学技术厅山东省重点研发计划(2017G006017):基于中医医疗与临床科研信息共享系统平台的子宫腺肌病辨证论治规律数据挖掘的研究,负责人:师伟
国家科学技术部国家重点研发计(2017YFC1703502):中医临床科研信息共享系统的研发与实施,负责人:杨杰
山东省科学技术厅山东省重天科技创新工程项目(2018CXGC1309):基于多维谱-效联合网络药理学关健技术的桂枝茯苓丸治疗子宫腺肌病的物质基础研究,负责人:师伟。
关键词
子宫腺肌病
数据挖掘
复杂网络分析
用药规律
中医药
Adenomyosis
Data mining
Complex network analysis
Medication rule
Chinese medicine