丁苯酞治疗血管性痴呆的疗效和作用机制

Therapeutic Effect and Mechanism of Butylphthalide on Vascular Dementia

目的研究丁苯酞在血管性痴呆(vascular dementia,VD)治疗中的疗效和作用机制。方法选择我院2018年6月—2019年6月收治的94例VD患者,随机分为对照组(47例,予以常规对症治疗)与试验组(47例,加用丁苯酞氯化钠注射液+丁苯酞软胶囊),比较两组的氧化应激反应、痴呆评分、认知功能、日常生活活动能力、临床疗效。结果(1)经治疗试验组氧化应激反应指标改善程度优于对照组(P<0.05);(2)治疗后试验组痴呆评分低于对照组,且认知功能评分、日常生活活动能力评分高于对照组,P<0.05;(3)试验组治疗总有效率(91.49%)优于对照组(74.47%),P<0.05。结论给予VD患者丁苯酞治疗,疗效显著。

Objective To study the effect and mechanism of butylphthalide in the treatment of vascular dementia(VD).Methods 94 VD patients admitted to our hospital from June 2018 to June 2019 were randomly divided into control group(47 cases,treated with routine symptomatic treatment)and experimental group(47 cases,added with sodium butylphthalide chloride).The oxidative stress reaction,dementia score,cognitive function,activity of daily life and clinical effect of the two groups were compared.Results(1)the improvement of oxidative stress in the treatment group was better than that in the control group(P<0.05);(2)the dementia score in the treatment group was lower than that in the control group,and the scores of cognitive function and activities of daily life were higher than that in the control group(P<0.05);(3)the total effective rate in the treatment group(91.49%)was better than that in the control group(74.47%),P<0.05.Conclusion The therapeutic effect of butylphthalide in VD patients is significant.