血清中铜、锌、镍、镉、锰等微量元素对稽留流产影响的研究

Study on the effect of trace elements such as copper,zinc,nickel,iron and manganese in serum on the missed abortion

目的探讨孕早期血清中汞、锰、镍、铜、锌、砷、镉、铅水平对稽留流产的影响,为稽留流产病因研究提供线索。方法选取同年龄段、同孕周的稽留流产患者及正常早孕者21对,检测两组孕妇血清汞、锰、镍、铜、锌、砷、镉、铅水平。采用1∶1配比Logistic回归分析模型分析稽留流产可能的影响因素。结果与正常早孕组相比,稽留流产组血清镍(t=3.57,P=0.002)、铜(t=7.94,P<0.001)、锌(t=3.60,P=0.002)、镉(t=4.74,P<0.001)、砷(t=2.82,P=0.011)、铅(t=3.46,P=0.002)水平较高,血清锰水平较低(t=-8.24,P<0.001);二元多因素Logistic回归分析模型分析结果显示,高血镍(OR=7.83,95%CI:1.03~59.68,P=0.037)、高血镉(OR=3.51,95%CI:2.53~4.87,P=0.004)为稽留流产的危险因素,高血锰(OR=0.68,95%CI:0.41~0.97,P=0.030)为保护性因素。结论孕妇血清中镍、镉、锰水平对稽留流产的发生有一定的影响,其机理有待于进一步研究。

Objective To investigate the effects of levels of mercury,manganese,nickel,copper,zinc,arsenic,cadmium,and lead in serum during early pregnancy on missed abortion,and to provide clues for the study of the cause of missed abortion.Methods Twenty-one pairs of aborted patients of the same age,with the same gestational age,and normal early pregnancy were selected,and the levels of serum mercury,manganese,nickel,copper,zinc,arsenic,cadmium,and lead in the two groups of pregnant women were detected.Multivariate Logistic regression was used to analyze the possible influencing factors of missed abortion.Results Compared with the normal early pregnancy group,the serum levels of nickel(t=3.57,P=0.002),copper(t=7.94,P<0.001),zinc(t=3.60,P=0.002),cadmium(t=4.74,P<0.001),arsenic(t=2.82,P=0.011),and lead(t=3.46,P=0.002)were higher in the missed abortion group,and the serum manganese levels were lower(t=-8.24,P<0.001).The binary multivariate logistic regression showed that the OR values of high blood nickel and high blood cadmium were 7.83(95%CI:1.03-59.68,P=0.037),3.51(95%CI:2.53-4.87,P=0.004)and 0.68(95%CI:0.47-0.97,P=0.034).Conclusion The levels of Ni,Cd and Mn in pregnant women’s serum have a certain effect on the occurrence of missed abortion,and its mechanism needs further study.