基于文献中药汤剂治疗口腔扁平苔藓的用药规律探讨

Discussion on the Rule of Compound Chinese Medicine Decoction for Premature Lichen Planus Based on Literature

目的:基于文献数据挖掘中药汤剂治疗扁平苔藓用药规律和特点,为扁平苔藓的中医临床治疗提供参考和借鉴。方法:检索9 808篇扁平苔藓的相关治疗文献,最终筛选出68篇中医临床对照观察类文献,并分别查出其药性、药味、功效及归经,运用Excel、SPSS 20.0、Weka 3.8、Cytoscape 3.6.1等软件对文献数据进行统计分析。结果:统计分析发现,治疗本病的高频药物为当归、生地黄、甘草、茯苓等,累计占总频次的59.30%以上,并从高频药物之间的关联规则中挖掘出最常用药对和药组搭配;从功效角度分析,以清热药为主,其次是补虚药、利水渗湿药等,累计占总频次的59.33%;从药性角度分析,主要以寒性为主,其次是温性、平性药物,三者累计占药性总频次的59.33%;从药味角度分析,以苦味最多,其次是甘、辛、淡味等,累计占药味总频次的58.84%;从药物归经角度分析,以归脾经药物为最,其次是归肝、心、肺、胃和肾经等药物,累计占归经总频次的62.80%。结论:从数据挖掘结果来看扁平苔藓的病因病机以肺脾气虚、湿毒内侵、肝肾亏虚、阴虚火热为主,临床上前期多以健脾利湿、清热解毒、活络止痛治法,后期以滋补肝肾、益气养阴之法治疗本病。该文献研究对扁平苔藓的中医治疗具有一定的临床借鉴和启示意义。

Objective:Based on literature data mining,the medication rules and characteristics of traditional Chinese medicine decoction in treating lichen planus can provide reference for clinical treatment of lichen planus.Methods:Retrieving 9808 literatures related to the treatment of lichen planus,68 clinical controlled observational literatures of traditional Chinese medicine were screened out,and their medicinal properties,taste,efficacy and meridian attribution were identified respectively.The literature data were analyzed by Excel,SPSS 20.0,Weka 3.8 and Cytoscape 3.6.1.Results:Statistical analysis found that the high-frequency drugs for the treatment of this disease were Angelica sinensis,Radix Rehmanniae,Glycyrrhizae,Poria cocos,accounting for 59.30% of the total frequency,and from the association rules between high-frequency drugs,the most commonly used drug pairs and drug group collocation were excavated;from the efficacy point of view,heat-clearing drugs were the main,followed by tonifying deficiency drugs,diuresis and dampness,etc.,which accounted for the total.The frequency was 59.33%.From the perspective of medicinal properties,chillness was the main factor,followed by warm and plain drugs,which accounted for 59.33% of the total frequency of medicinal properties.From the perspective of medicinal taste,bitterness was the most important factor,followed by Gan,Xin and light taste,which accounted for 58.84% of the total frequency of medicinal taste;from the perspective of medicinal meridian,spleen meridian medicine was the most important factor,followed by liver medicine and light medicine.Heart,lung,stomach and kidney meridians accounted for62.80% of the total frequency of meridian attribution.Conclusion:From the results of data mining,we can see that the etiology and pathogenesis of lichen planus are mainly lung-qi deficiency,dampness-toxin intrusion,liver-kidney deficiency,Yin deficiency and fireheat.Clinically,the methods of invigorating spleen and dampness,clearing heat and detoxifying toxins,activating collaterals and relieving pain are mostly used in the early stage,and nourishing liver and kidney,invigorating qi and nourishing yin in the later stage.This literature study has certain clinical reference and enlightenment significance for the treatment of lichen planus in traditional Chinese medicine.