射血分数保留心力衰竭患者NT-proBNP、UA及Hcy水平与心功能的相关性

Correlations between levels of NT-proBNP,UA,Hcy levels and cardiac function in heart failure patients with preserved ejection fraction

目的分析射血分数保留的心力衰竭患者血清N末端B型利钠肽原(N-terminal pro-B type natriuretic peptide,NT-proBNP)、尿酸(uric acid,UA)及同型半胱氨酸(homocysteine,Hcy)水平与心功能的相关性。方法选取2016-02至2019-05珠海高新技术产业开发区人民医院收治的88例射血分数保留的心力衰竭患者作为观察组,并根据纽约心脏病协会(new york heart association,NYHA)心功能分级,将患者分为Ⅱ~Ⅳ级,同时选取同期心功能正常的30例体检者作为对照组,分析血清NT-proBNP、UA及Hcy水平与心功能的相关性。结果观察组患者的NT-proBNP、UA及Hcy水平均明显高于对照组,且随着心功能等级提高,各指标水平呈明显上升趋势,差异均有统计学意义(P<0.05);经Spearman等级相关分析显示,射血分数保留心力衰竭患者的血清NT-proBNP、UA及Hcy水平与心功能呈正相关(ρ>0.6,P<0.05)。结论射血分数保留心力衰竭患者的血清NT-proBNP、UA、Hcy水平与其心功能呈正相关。

Objective To explore correlations between levels of serum N-terminal proB-type natriuretic peptide(NT-proBNP),uric Acid(UA),serum homocysteine(Hcy)and cardiac function in heart failure patients with preserved ejection fraction.Methods 88 heart failure patients with preserved ejection fraction admitted to People's Hospital of Zhuhai Hitech Industrial Development Zone from February 2016 to May 2019 were selected as observation group,and were classified into II-IV grade according to New York Heart Association(NYHA)cardiac function classification system.30 patients for health examination with normal cardiac function during the same period were selected as the control group.The correlations between the levels of serum NT-proBNP,UA,Hcy levels and cardiac function were analyzed.Results The levels of NT-proBNP,UA,and Hcy in the observation group were significantly higher than those in the control group;as the cardiac function grade increased,each index showed a significant upward trend;and the differences were statistically significant(P<0.05).Spearman rank correlation analysis showed that the serum NT-proBNP,UA,and Hcy levels in the heart failure patients with preserved ejection fraction were positively correlated with the cardiac function(ρ>0.6,P<0.05).Conclusions The serum NT-proBNP,UA,and Hcy levels in the heart failure patients with preserved ejection fraction are positively correlated with the cardiac function.