1型糖尿病妇女妊娠期间胰岛素应用剂量研究

Study on Insulin Dosage during Pregnancy in Type 1 Diabetic Women

目的:研究胰岛素泵1型糖尿病妇女妊娠期间胰岛素应用剂量。方法:选择2016年12月~2017年12月某院收治的1型糖尿病妊娠妇女15例,记录患者孕前胰岛素使用情况、孕期胰岛素及血糖控制情况及妊娠结局情况。结果:随着患者妊娠时间延长,胰岛素的摄入量逐渐增加,且孕中期、孕晚期与孕前相比均具有统计学差异(P<0.05)。患者孕中期及孕晚期胰岛素总量摄入较孕前相比增加分别为35.48%和66.13%;孕早期胰岛素基础量较孕前相比降低6.06%,孕中期及晚期分别增加9.09%和15.15%;孕早期,中期及晚期胰岛素大剂量较孕前相比增加10.34%、103.45%及134.48%;孕早期,中期及晚期胰岛素大剂量比例较孕前增加8.50%、28.17%和39.76%。结论:1型糖尿病妊娠妇女随着孕周期延长胰岛素需求量逐渐增加,在临床工作中应该根据孕周期调整胰岛素摄入量。

Objective:To study insulin dosage during pregnancy in type 1 diabetic women. Methods:15 pregnant women with type 1 diabetes admitted to a hospital from December 2012 to December 2017 were selected. The pre-pregnancy insulin use, insulin and blood glucose control during pregnancy, and pregnancy outcomes were recorded. Results: With the prolongation of pregnancy, insulin intake gradually increased, and there were statistical differences between the second and third trimester of pregnancy and pre-pregnancy(P<0.05). Total insulin intake in the second and third trimester of pregnancy increased by 35.48% and 66.13%, respectively, compared with that before pregnancy. The basal amount of insulin in early pregnancy decreased by 6.06% compared with that before pregnancy, and increased by 9.09% and 15.15% in the second and third trimesters, respectively;The high dose of insulin in early, middle and late pregnancy increased by 10.34%, 103.45% and 134.48% compared with that before pregnancy. The proportion of high dose insulin in early, middle and late pregnancy increased by 8.50%, 28.17% and 39.76% compared with that before pregnancy. Conclusion:With the prolongation of gestational cycle, the demand for insulin in type 1 diabetic pregnant women increases gradually, insulin intake should be adjusted according to the pregnancy cycle.