铝碳酸镁咀嚼片联合奥美拉唑治疗胃溃疡的疗效研讨

Study on the Efficacy of Magnesium Aluminate Chewable Tablets Combined with Omeprazole in the Treatment of Gastric Ulcer

目的:探讨铝碳酸镁咀嚼片及奥美拉唑联合治疗胃溃疡的临床效果及安全性。方法:选取某院胃溃疡患者118例(2015年11月~2018年11月),随机数字表法分为研究组与对照组各59例,对照组采取奥美拉唑四联疗法,研究组于对照组基础上加用铝碳酸镁咀嚼片,均治疗4周。统计两组临床疗效、治疗前及疗程结束后生活质量(SF-36)分值、不良反应(眩晕、呕吐恶心、胃肠胀气、失眠)。结果:研究组总有效率94.92%(56/59)高于对照组83.05%(49/59)(P<0.05);两组疗程结束后SF-36高于治疗前(P<0.05),且研究组较对照组高(P<0.05);研究组不良反应发生率13.56%(8/59)与对照组10.17%(6/59)间无显著差异(P>0.05)。结论:联合采取奥美拉唑及铝碳酸镁咀嚼片治疗胃溃疡,可有效提高疾病整体治疗疗效,利于改善患者生活质量,且不会增加不良反应发生风险,具有安全性。

Objective:To investigate the clinical effect and safety of magnesium aluminate chewable tablets combined with omeprazole in the treatment of gastric ulcer. Methods:118 patients with gastric ulcer in a hospital(from November 2015 to November 2018) were selected and randomly divided into study group(n=59) and control group(n=59). The control group was treated with omeprazole quadruple therapy, and the study group was treated with Magnesium Aluminium Carbonate Chewable Tablets on the basis of the controlgroup for 4 weeks.The clinical efficacy,quality of life(SF-36)score,adverse reactions(vertigo,vomiting,nausea,gastrointestinal distention,insomnia)before and after treatment were analyzed.Results:The total effective rate of the study group was 94.92%(56/59),higher than that of the control group with 83.05%(49/59)(P<0.05);The SF-36 of the two groups was higher than that before treatment(P<0.05);There was no significant difference in the incidence of adverse reactions between the study group with 13.56%(8/59)and the control group with 10.17%(6/59)(P>0.05).Conclusion:The combination of omeprazole and magnesium aluminate chewable tablets in the treatment of gastric ulcer can effectively improve the overall therapeutic effect of the disease.It is conducive to improving the quality of life of patients,and will not increase the risk of adverse reactions,which is safe.