中药丹参治疗骨质疏松的作用及其机制

Study on the Treatment of Osteoporosis with Salvia Miltiorrhiza

丹参为唇形科植物丹参(Salvia miltiorrhiza Bge.)的干燥根及根茎,广泛用于治疗心脑血管疾病,近年来研究发现丹参可通过RANK/RANKL/OPG信号通路、FoxO/Wnt信号通路、作为组织蛋白酶K抑制剂等作用,促进骨骼的生长与愈合,预防个体骨骼的损伤和坏死,有效降低老年人或绝经期妇女骨吸收生物指标,达到治疗骨质疏松的作用。本文现就丹参及其活性成分、对骨质疏松的治疗作用及其机制研究进行综述。

Salvia miltiorrhiza is the dried root and rhizome of(Salvia miltiorrhiza Bge.),which is widely used in the treatment of cardiovascular and cerebrovascular diseases. In recent years, it has been found that salvia miltiorrhiza can pass the RANK/RANKL/OPG signaling pathway, FoxO/Wnt signaling pathway As a cathepsin K inhibitor, it can promote the growth and healing of bones, prevent the damage and necrosis of individual bones,effectively reduce the biological indicators of bone resorption in elderly or menopausal women, and achieve the effect of treating osteoporosis. This article now reviews the research on salvia miltiorrhiza and its active ingredients, its therapeutic effect on osteoporosis and its mechanism.