更年期患者睡眠质量调查及干预对策研究

Investigation on Sleep Quality of Menopausal Patients and Intervention Strategies

目的:探究更年期患者睡眠质量调查及干预对策研究。方法:选取2017年1月至2018年8月来辽宁省庄河市中心医院进行体检的正常人作为对照组(CO组),来就诊的更年期患者作为观察组(EX组),每组42例。EX组患者按照不同的治疗方法分组,第一组,基础观察组(BT组)本组患者采用服用克龄蒙来治疗更年期综合征;第二组,盐酸曲唑酮组(TH组)本组患者在BT组+盐酸曲唑酮来治疗更年期综合征。通过分析EX组和CO组患者睡眠质量情况、BT组和TH组患者治疗效果、单胺类递质表达水平的差异性来探究更年期患者睡眠质量调查及干预对策研究。结果:EX组和CO组患者总PSQI评分分别为(15.11±4.51)、(5.85±2.23)分,其中,EX组患者睡眠时间、效率、障碍等因子均高于CO组,EX组和CO组比较,EX组患者睡眠质量情况显著优于CO组(P<0.05)。由表可知,治疗后,BT组患者有显著治疗效果12例,无显著治疗效果9例,TH组患者有显著治疗效果19例,无显著治疗效果2例,BT组和TH组比较,TH组患者的最终治疗结果明显比BT组优(P<0.05)。由结果表明,治疗前,BT组和TH组患者单胺类递质表达水平相近,数值相差较小(P>0.05),治疗后,2组患者单胺类递质表达水平均有显著改变,BT组和TH组比较,TH组患者的5-HT、NE表达水平显著优于BT组(P<0.05)。结论:更年期患者与同期健康人群比较,前者睡眠质量显著下降,可以通过药物干预来进行治疗,且效果显著。

Objective:To explore the sleep quality survey and intervention strategies of menopausal patients.Methods:In the future,the normal subjects who underwent physical examination in our hospital were used as the control group(CO group),and the menopausal patients who were treated in our hospital were used as the experimental group(EX group).Patients in the EX group were divided according to different treatment methods.The first group,the basic treatment group(BT group):the patients in this group were treated with kemeng Meng to treat climacteric syndrome;the second group was treated with trazodone hydrochloride group(TH group).This group of patients in the BT group+trazodone hydrochloride to treat climacteric syndrome.There were no differences in general data between the BT group and the TH group.By analyzing the sleep quality of patients in the EX group and the CO group,the therapeutic effects of the BT group and the TH group,and the differences in the expression levels of monoamine transmitters,the sleep quality survey and intervention strategies of menopausal patients were explored.Results:The total PSQI scores of patients in the EX group and the CO group were(15.11±4.51)and(5.85±2.23),respectively.Among them,the sleep time,efficiency,and obstacles of the EX group were higher than those of the CO group,and the EX group and the CO group were compared.The sleep quality of the patients was significantly better than that of the CO group(P<0.05).It can be seen from the table that after treatment,the patients in the BT group had a significant therapeutic effect of 12 patients,and there were no significant therapeutic effects in 9 patients.The TH group had significant therapeutic effects in 19 patients,and there was no significant therapeutic effect in 2 patients.Compared with the TH group,the TH group was compared with the TH group.The final treatment outcome was significantly better in the group than in the BT group(P<0.05).The results showed that before treatment,the expression levels of monoamine transmitters in BT group and TH group were similar,and the difference was small(P>0.05).After treatment,the expression levels of monoamine transmitters in the two groups were significantly changed.Compared with the TH group,the expression levels of 5-HT and NE in the TH group were significantly better than those in the BT group(P<0.05).Conclusion:Compared with healthy people in the same period,the quality of sleep in the former menopausal patients is significantly reduced,and it can be treated by drug intervention,and the effect is remarkable.