从“菌-炎-宿主”关系探讨中医药治疗幽门螺杆菌胃炎思路

Thinking of treating Helicobacter pylori gastritis with TCM basing on the relationship of Helicobacter pylori-inflammation-host

幽门螺杆菌(H.pylori)是慢性胃炎及胃黏膜炎症损伤的主要病因。目前治疗H.pylori抗生素的耐药率逐年增高,联合中医药治疗或中医药辨治是抗H.pylori感染的有效途径。“病-证”结合、辨证论治是中医药治疗H.pylori及其相关疾病的基本原则。中医药治疗H.pylori胃炎的关键是减轻胃黏膜慢性炎症损伤,并调节宿主免疫和胃肠道菌群状态。中医药重视通过扶正祛邪,调节重建宿主及胃黏膜平衡稳态,从而达到治疗H.pylori胃炎的作用。总之,中医药辨治H.pylori胃炎是一种多靶点作用、综合影响干预的有效治疗方法。

Helicobacter pylori(H.pylori)is the leading cause of chronic inflammation and inflammatory lesion of gastric mucosa.Antibiotic resistance of H.pylori is increasing around the world,so antibiotic treatment combined with traditional Chinese medicine(TCM)or syndrome differentiation treatment with TCM are effective ways to overcome H.pylori.Integration of disease and syndrome,and syndrome differentiation treatment are the basic rules of TCM in the treatment of H.pylori infection and related diseases.The keys to the treatment of H.pylori gastritis with TCM are to alleviate the chronic inflammatory lesion of gastric mucosa,regulate host immunity and adjust gastrointestinal microbiota.TCM pays more attention to regulating and restoring the homeostasis of the host and the gastric mucosa in the treatment of H.pylori gastritis by the therapeutic methods of strengthening healthy qi to eliminate pathogens.In conclusion,TCM is a useful kind of multi-target and comprehensive therapeutic approach for H.pylori gastritis.