甘草附子汤与针灸联合艾瑞昔布治疗强直性脊柱炎临床研究

Clinical Study of Gancao Fuzi Tang and Acupuncture Combined with Imrecoxib for Ankylosing Spondylitis

目的:观察甘草附子汤与针灸联合艾瑞昔布治疗强直性脊柱炎患者预后。方法:将96例患者分为2组各48例,对照组给予艾瑞昔布片,观察组在对照组基础上给予甘草附子汤与针灸治疗。对比2组患者治疗前后疾病的总体评价(PGA)、病情活动指数(BASDAI)评分、肿瘤坏死因子-α(TNF-α)、白细胞介素-6 (IL-6)、C-反应蛋白(CRP)、肠球菌表面蛋白(ESP)、脊柱痛评分、晨僵时间、枕墙距、扩胸度。结果:治疗后,2组PGA评分、BASDAI评分均较前改善(P<0.05)。观察组治疗后PGA评分、BASDAI评分较对照组降低,差异有统计学意义(P<0.05)。治疗后,2组炎症指标均较前改善(P<0.05)。观察组治疗后TNF-α、IL-6、CRP、ESP与对照组比较,差异有统计学意义(P<0.05)。治疗后,2组脊柱疼痛评分、晨僵时间、枕墙距均下降,扩胸度均提高(P<0.05)。观察组治疗后脊柱疼痛评分、晨僵时间、枕墙距与对照组相比明显降低,而扩胸度则较对照组有所提高,差异有统计学意义(P<0.05)。结论:甘草附子汤与针灸联合艾瑞昔布治疗强直性脊柱炎,相比单一西医药物治疗更能有效的改善患者临床症状,明显降低炎性水平,提高关节功能,可促进患者预后。

Objective: To observe the prognosis of Gancao Fuzi tang and acupuncture combined with imrecoxib for patients with ankylosing spondylitis. Methods:Divided 96 cases into two groups,48 cases in each group. The control group was treated with imrecoxib,while the observation group was treated with Gancao Fuzi tang and acupunture based on the treatment of the control group. Before and after treatment,the scores of Patient Global Assessment(PGA),Bath Ankylosing Spondylitis Disease Activity Index(BASDAI) and spinal pain and the indexes including tumor necrosis factor-α(TNF-α), interleukin-6(IL-6), C-reactive protein(CRP), enterococcus surface protein(ESP), time of morning stiffness,occiput to wall distance,and chest expansion in the two groups were compared. Results:After treatment,the scores of PGA and BASDAI in the two groups were improved when compared with those before treatment(P<0.05). After treatment,the above scores in the observation group were lower than those in the control group,the difference being significant(P<0.05). After treatment,inflammatory indexes in the two groups were improved when compared with those before treatment(P<0.05). After treatment,there was significant difference being found in the comparison of the indexes of TNF-α,IL-6,CRP and ESP between the two groups(P<0.05). After treatment, the scores of spinal pain, time of morning stiffness,occiput to wall distance in the two groups were decreased,and chest expansion was increased(P<0.05). After treatment,the score of spinal pain, time of morning stiffness, occiput to wall distance in the observation group were significantly decreased when compared with those in the control group,while chest expansion was improved when compared with that in the control group, the difference being significant(P<0.05). Conclusion: When compared with that of the simple western medicine treatment, the therapy of Gancao Fuzi tang and acupuncture combined with imrecoxib is more effective in improving the clinical symptoms of patients, which can significantly reduce the inflammatory levels, improve the joint function,and promote the prognosis of patients.